Apparent Maximum Rate in presence of Noncompetitive Inhibitor Calculator

✖The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration.ⓘ Maximum Rate [V_max]			+10% -10%
✖The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.ⓘ Inhibitor Concentration [I]			+10% -10%
✖The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.ⓘ Enzyme Inhibitor Dissociation Constant [K_i]			+10% -10%

✖Apparent Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration in presence of non-competitive inhibitor.ⓘ Apparent Maximum Rate in presence of Noncompetitive Inhibitor [Vmax^app]

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Formula

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Apparent Maximum Rate in presence of Noncompetitive Inhibitor

Formula

`"Vmax"^{"app"} = ("V"_{"max"}/(1+("I"/"K"_{"i"})))`

Example

`"27.14286mol/L*s"=("40mol/L*s"/(1+("9mol/L"/"19mol/L")))`

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Apparent Maximum Rate in presence of Noncompetitive Inhibitor Solution

STEP 0: Pre-Calculation Summary

Formula Used

Apparent Maximum Rate = (Maximum Rate/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant)))
Vmax^app = (V_max/(1+(I/K_i)))
This formula uses 4 Variables

Variables Used

Apparent Maximum Rate - (Measured in Mole per Cubic Meter Second) - Apparent Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration in presence of non-competitive inhibitor.
Maximum Rate - (Measured in Mole per Cubic Meter Second) - The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration.
Inhibitor Concentration - (Measured in Mole per Cubic Meter) - The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.
Enzyme Inhibitor Dissociation Constant - (Measured in Mole per Cubic Meter) - The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.

STEP 1: Convert Input(s) to Base Unit

Maximum Rate: 40 Mole per Liter Second --> 40000 Mole per Cubic Meter Second (Check conversion here)
Inhibitor Concentration: 9 Mole per Liter --> 9000 Mole per Cubic Meter (Check conversion here)
Enzyme Inhibitor Dissociation Constant: 19 Mole per Liter --> 19000 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

Vmax^app = (V_max/(1+(I/K_i))) --> (40000/(1+(9000/19000)))

Evaluating ... ...

Vmax^app = 27142.8571428571

STEP 3: Convert Result to Output's Unit

27142.8571428571 Mole per Cubic Meter Second -->27.1428571428571 Mole per Liter Second (Check conversion here)

FINAL ANSWER

27.1428571428571 ≈ 27.14286 Mole per Liter Second <-- Apparent Maximum Rate

(Calculation completed in 00.004 seconds)

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K J Somaiya College of science (K J Somaiya), Mumbai

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< 9 Noncompetitive Inhibitor Calculators

Dissociation Constant given Enzyme Substrate Complex Concentration

Go Enzyme Inhibitor Dissociation Constant = Inhibitor Concentration/(((((Initial Enzyme Concentration*Substrate Concentration)/Enzyme Substrate Complex Concentration)-Substrate Concentration)/Michaelis Constant)-1)

Apparent Initial Enzyme Concentration in Presence of Noncompetitive Inhibitor

Go Apparent Initial Enzyme Concentration = (Initial Enzyme Concentration/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant)))

Initial Enzyme Concentration in presence of Noncompetitive Inhibitor

Go Initial Enzyme Concentration = (Apparent Initial Enzyme Concentration*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant)))

Dissociation Constant given Apparent Initial Enzyme Concentration

Go Enzyme Inhibitor Dissociation Constant = (Inhibitor Concentration/((Initial Enzyme Concentration/Apparent Initial Enzyme Concentration)-1))

Apparent Michaelis Menten constant given Inhibitor's Dissociation Constant

Go Apparent Michaelis Constant = Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))

Apparent Maximum Rate in presence of Noncompetitive Inhibitor

Go Apparent Maximum Rate = (Maximum Rate/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant)))

Dissociation Constant in presence of Noncompetitive Inhibitor

Go Enzyme Inhibitor Dissociation Constant = (Inhibitor Concentration/((Maximum Rate/Apparent Maximum Rate)-1))

Maximum Rate in presence of Noncompetitive Inhibitor

Go Maximum Rate = (Apparent Maximum Rate*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant)))

Inhibitor Concentration in presence of Noncompetitive Inhibitor

Go Inhibitor Concentration = ((Maximum Rate/Apparent Maximum Rate)-1)*Enzyme Inhibitor Dissociation Constant

Apparent Maximum Rate in presence of Noncompetitive Inhibitor Formula

Apparent Maximum Rate = (Maximum Rate/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant)))
Vmax^app = (V_max/(1+(I/K_i)))

What is Non-competitive inhibition?

Non-competitive inhibition is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme and binds equally well to the enzyme whether or not it has already bound the substrate. In the presence of a non-competitive inhibitor, the apparent enzyme affinity is equivalent to the actual affinity because the inhibitor binds to both the enzyme and the enzyme-substrate complex equally so that the equilibrium is maintained. However, since some enzyme is always inhibited from converting the substrate to product, the effective enzyme concentration is lowered.

How to Calculate Apparent Maximum Rate in presence of Noncompetitive Inhibitor?

Apparent Maximum Rate in presence of Noncompetitive Inhibitor calculator uses Apparent Maximum Rate = (Maximum Rate/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))) to calculate the Apparent Maximum Rate, The Apparent maximum rate in presence of noncompetitive inhibitor formula is defined as relation to the maximum rate of the system, inhibitor concentration, and dissociation constant. Apparent Maximum Rate is denoted by Vmax^app symbol.

How to calculate Apparent Maximum Rate in presence of Noncompetitive Inhibitor using this online calculator? To use this online calculator for Apparent Maximum Rate in presence of Noncompetitive Inhibitor, enter Maximum Rate (V_max), Inhibitor Concentration (I) & Enzyme Inhibitor Dissociation Constant (K_i) and hit the calculate button. Here is how the Apparent Maximum Rate in presence of Noncompetitive Inhibitor calculation can be explained with given input values -> 0.027143 = (40000/(1+(9000/19000))).

FAQ

What is Apparent Maximum Rate in presence of Noncompetitive Inhibitor?

The Apparent maximum rate in presence of noncompetitive inhibitor formula is defined as relation to the maximum rate of the system, inhibitor concentration, and dissociation constant and is represented as Vmax^app = (V_max/(1+(I/K_i))) or Apparent Maximum Rate = (Maximum Rate/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))). The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration, The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system & The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.

How to calculate Apparent Maximum Rate in presence of Noncompetitive Inhibitor?

The Apparent maximum rate in presence of noncompetitive inhibitor formula is defined as relation to the maximum rate of the system, inhibitor concentration, and dissociation constant is calculated using Apparent Maximum Rate = (Maximum Rate/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))). To calculate Apparent Maximum Rate in presence of Noncompetitive Inhibitor, you need Maximum Rate (V_max), Inhibitor Concentration (I) & Enzyme Inhibitor Dissociation Constant (K_i). With our tool, you need to enter the respective value for Maximum Rate, Inhibitor Concentration & Enzyme Inhibitor Dissociation Constant and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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