Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex Calculator

✖The Enzyme Substrate Modifying Factor is defined by the inhibitor concentration and the dissociation constant of the enzyme-substrate complex.ⓘ Enzyme Substrate Modifying Factor [α^']			+10% -10%
✖The Enzyme Substrate Dissociation Constant is difficult to measure directly since the enzyme-substrate complex is short-lived and undergoes a chemical reaction to form the product.ⓘ Enzyme Substrate Dissociation Constant [K_i']			+10% -10%

✖The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.ⓘ Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex [I]

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Formula

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Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex

Formula

`"I" = ("α"^{"'"}-1)*("K"_{"i"}"'")`

Example

`"15mol/L"=("2"-1)*"15mol/L"`

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Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex Solution

STEP 0: Pre-Calculation Summary

Formula Used

Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant
I = (α^'-1)*K_i'
This formula uses 3 Variables

Variables Used

Inhibitor Concentration - (Measured in Mole per Cubic Meter) - The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.
Enzyme Substrate Modifying Factor - The Enzyme Substrate Modifying Factor is defined by the inhibitor concentration and the dissociation constant of the enzyme-substrate complex.
Enzyme Substrate Dissociation Constant - (Measured in Mole per Cubic Meter) - The Enzyme Substrate Dissociation Constant is difficult to measure directly since the enzyme-substrate complex is short-lived and undergoes a chemical reaction to form the product.

STEP 1: Convert Input(s) to Base Unit

Enzyme Substrate Modifying Factor: 2 --> No Conversion Required
Enzyme Substrate Dissociation Constant: 15 Mole per Liter --> 15000 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

I = (α^'-1)*K_i' --> (2-1)*15000

Evaluating ... ...

I = 15000

STEP 3: Convert Result to Output's Unit

15000 Mole per Cubic Meter -->15 Mole per Liter (Check conversion here)

FINAL ANSWER

15 Mole per Liter <-- Inhibitor Concentration

(Calculation completed in 00.004 seconds)

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Go Initial Enzyme Concentration = ((Reverse Rate Constant*Enzyme Substrate Complex Concentration)/(Forward Rate Constant*Substrate Concentration))+Enzyme Substrate Complex Concentration

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Go Catalyst Concentration = ((Reverse Rate Constant+Catalytic Rate Constant)*Enzyme Substrate Complex Concentration)/(Forward Rate Constant*Substrate Concentration)

Substrate Concentration given Forward, Reverse, and Catalytic Rate Constants

Go Substrate Concentration = ((Reverse Rate Constant+Catalytic Rate Constant)*Enzyme Substrate Complex Concentration)/(Forward Rate Constant*Catalyst Concentration)

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Go Initial Enzyme Concentration = (Initial Reaction Rate*(Dissociation Rate Constant+Substrate Concentration))/(Catalytic Rate Constant*Substrate Concentration)

Substrate Concentration given Catalytic Rate Constant and Dissociation Rate Constants

Go Substrate Concentration = (Dissociation Rate Constant*Initial Reaction Rate)/((Catalytic Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate)

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Go Concentration of Substrate = (Michaelis Constant*Initial Reaction Rate)/((Catalytic Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate)

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Go Substrate Concentration = (Dissociation Rate Constant*Enzyme Substrate Complex Concentration)/(Initial Enzyme Concentration-Enzyme Substrate Complex Concentration)

Initial Enzyme Concentration given Dissociation Rate Constant

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Inhibitor Concentration given Apparent Initial Enzyme Concentration

Go Inhibitor Concentration for CI = ((Initial Enzyme Concentration/Apparent Initial Enzyme Concentration)-1)*Enzyme Inhibitor Dissociation Constant

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Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex

Go Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant

Inhibitor Concentration given Enzyme Substrate Modifying Factor

Go Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant

Inhibitor Concentration given Modifying Factor of Enzyme

Go Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant

Enzyme Substrate Complex Concentration given Rate Constant and Initial Rate

Go Enzyme Inhibitor Complex Concentration = (Initial Reaction Rate/Final Rate Constant)

Initial Enzyme Concentration given Rate Constant and Maximum Rate

Go Initial Enzyme Concentration = Maximum Rate/Final Rate Constant

Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex Formula

Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant
I = (α^'-1)*K_i'

What is competitive Inhibition?

In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time, as shown in the figure on the right. This usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate and inhibitor compete for access to the enzyme's active site. This type of inhibition can be overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. However, the apparent Km will increase as it takes a higher concentration of the substrate to reach the Km point, or half the Vmax. Competitive inhibitors are often similar in structure to the real substrate.

How to Calculate Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex?

Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex calculator uses Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant to calculate the Inhibitor Concentration, The Inhibitor concentration given modifying factor of enzyme substrate complex formula is defined as the relation with the modifying factor of enzyme-substrate complex and with a dissociation constant of enzyme-substrate complex of the system. Inhibitor Concentration is denoted by I symbol.

How to calculate Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex using this online calculator? To use this online calculator for Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex, enter Enzyme Substrate Modifying Factor (α^') & Enzyme Substrate Dissociation Constant (K_i') and hit the calculate button. Here is how the Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex calculation can be explained with given input values -> 0.015 = (2-1)*15000.

FAQ

What is Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex?

The Inhibitor concentration given modifying factor of enzyme substrate complex formula is defined as the relation with the modifying factor of enzyme-substrate complex and with a dissociation constant of enzyme-substrate complex of the system and is represented as I = (α^'-1)*K_i' or Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant. The Enzyme Substrate Modifying Factor is defined by the inhibitor concentration and the dissociation constant of the enzyme-substrate complex & The Enzyme Substrate Dissociation Constant is difficult to measure directly since the enzyme-substrate complex is short-lived and undergoes a chemical reaction to form the product.

How to calculate Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex?

The Inhibitor concentration given modifying factor of enzyme substrate complex formula is defined as the relation with the modifying factor of enzyme-substrate complex and with a dissociation constant of enzyme-substrate complex of the system is calculated using Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant. To calculate Inhibitor Concentration given Modifying Factor of Enzyme Substrate Complex, you need Enzyme Substrate Modifying Factor (α^') & Enzyme Substrate Dissociation Constant (K_i'). With our tool, you need to enter the respective value for Enzyme Substrate Modifying Factor & Enzyme Substrate Dissociation Constant and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Inhibitor Concentration?

In this formula, Inhibitor Concentration uses Enzyme Substrate Modifying Factor & Enzyme Substrate Dissociation Constant. We can use 2 other way(s) to calculate the same, which is/are as follows -

Inhibitor Concentration = (Enzyme Modifying Factor-1)*Enzyme Inhibitor Dissociation Constant
Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant

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