Plasma Volume of Drug given Apparent Volume Solution

STEP 0: Pre-Calculation Summary
Formula Used
Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
VP = Vd-(VT*(fu/fut))
This formula uses 5 Variables
Variables Used
Plasma Volume - (Measured in Cubic Meter) - Plasma Volume is the measurement in which a drug is distributed in blood plasma.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Apparent Tissue Volume - (Measured in Cubic Meter) - Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.
Fraction Unbound in Plasma - Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.
Fraction Unbound in Tissue - Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.
STEP 1: Convert Input(s) to Base Unit
Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
Apparent Tissue Volume: 3.5 Liter --> 0.0035 Cubic Meter (Check conversion here)
Fraction Unbound in Plasma: 0.99 --> No Conversion Required
Fraction Unbound in Tissue: 0.7 --> No Conversion Required
STEP 2: Evaluate Formula
Substituting Input Values in Formula
VP = Vd-(VT*(fu/fut)) --> 0.009-(0.0035*(0.99/0.7))
Evaluating ... ...
VP = 0.00405
STEP 3: Convert Result to Output's Unit
0.00405 Cubic Meter -->4.05 Liter (Check conversion here)
FINAL ANSWER
4.05 Liter <-- Plasma Volume
(Calculation completed in 00.004 seconds)

Credits

Created by Prashant Singh
K J Somaiya College of science (K J Somaiya), Mumbai
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11 Plasma Calculators

Fractional Excretion of Sodium
Go Fractional Excretion of Sodium = (Urine Sodium Concentration*Creatinine Concentration in Plasma)/(Sodium Concentration in Plasma*Creatinine Concentration in Urine)*100
Apparent Tissue Volume given Plasma Volume and Apparent Volume
Go Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
Plasma Volume of Drug given Apparent Volume
Go Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
Renal Clearance using Rate of Reabsorption
Go Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration
Average Plasma Concentration given Peak through Fluctuation
Go Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation
Lowest Plasma Concentration Given Peak through Fluctuation
Go Lowest Plasma Concentration = Peak Plasma Concentration-(Average Plasma Concentration*Peak Through Fluctuation)
Peak Plasma Concentration Given Peak through Fluctuation
Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration
Peak through Fluctuation
Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration
Average Concentration of Plasma at Steady State
Go Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
Plasma Concentration of Constant Rate Infusion at Steady State
Go Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance
Initial Concentration for Intravenous Bolus
Go Initial Plasma Concentration = Dose/Volume of Distribution

Plasma Volume of Drug given Apparent Volume Formula

Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
VP = Vd-(VT*(fu/fut))

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Plasma Volume of Drug given Apparent Volume?

Plasma Volume of Drug given Apparent Volume calculator uses Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)) to calculate the Plasma Volume, The Plasma volume of drug given apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue. Plasma Volume is denoted by VP symbol.

How to calculate Plasma Volume of Drug given Apparent Volume using this online calculator? To use this online calculator for Plasma Volume of Drug given Apparent Volume, enter Volume of Distribution (Vd), Apparent Tissue Volume (VT), Fraction Unbound in Plasma (fu) & Fraction Unbound in Tissue (fut) and hit the calculate button. Here is how the Plasma Volume of Drug given Apparent Volume calculation can be explained with given input values -> 4050 = 0.009-(0.0035*(0.99/0.7)).

FAQ

What is Plasma Volume of Drug given Apparent Volume?
The Plasma volume of drug given apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue and is represented as VP = Vd-(VT*(fu/fut)) or Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)). The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body, Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue, Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma & Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.
How to calculate Plasma Volume of Drug given Apparent Volume?
The Plasma volume of drug given apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue is calculated using Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)). To calculate Plasma Volume of Drug given Apparent Volume, you need Volume of Distribution (Vd), Apparent Tissue Volume (VT), Fraction Unbound in Plasma (fu) & Fraction Unbound in Tissue (fut). With our tool, you need to enter the respective value for Volume of Distribution, Apparent Tissue Volume, Fraction Unbound in Plasma & Fraction Unbound in Tissue and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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