Amount of drug administered given area under curve Calculator

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Dose

Area under curve

Bioavailability

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Drug Stability

Elimination Rate Constant

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Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared [CL]			+10% -10%
✖Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.ⓘ Area Under Curve [AUC]			+10% -10%

✖The Dose is the amount of drug administered.ⓘ Amount of drug administered given area under curve [D]

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Formula

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Amount of drug administered given area under curve

Formula

`"D" = "CL"*"AUC"`

Example

`"0.6336mol"="0.48L/s"*"1.320mol*s/L"`

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Amount of drug administered given area under curve Solution

STEP 0: Pre-Calculation Summary

Formula Used

Dose = Volume of Plasma Cleared*Area Under Curve
D = CL*AUC
This formula uses 3 Variables

Variables Used

Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.
Area Under Curve - (Measured in Mole Second per Cubic Meter) - Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.

STEP 1: Convert Input(s) to Base Unit

Volume of Plasma Cleared: 0.48 Liter per Second --> 0.00048 Cubic Meter per Second (Check conversion here)
Area Under Curve: 1.32 Mole Second per Liter --> 1320 Mole Second per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

D = CL*AUC --> 0.00048*1320

Evaluating ... ...

D = 0.6336

STEP 3: Convert Result to Output's Unit

0.6336 Mole --> No Conversion Required

FINAL ANSWER

0.6336 Mole <-- Dose

(Calculation completed in 00.020 seconds)

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Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

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University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Amount of drug administered given area under curve Formula

Dose = Volume of Plasma Cleared*Area Under Curve
D = CL*AUC

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Amount of drug administered given area under curve?

Amount of drug administered given area under curve calculator uses Dose = Volume of Plasma Cleared*Area Under Curve to calculate the Dose, The Amount of drug administered given area under curve formula is defined as the product of the volume of plasma cleared of the drug per unit time to the area under the curve. Dose is denoted by D symbol.

How to calculate Amount of drug administered given area under curve using this online calculator? To use this online calculator for Amount of drug administered given area under curve, enter Volume of Plasma Cleared (CL) & Area Under Curve (AUC) and hit the calculate button. Here is how the Amount of drug administered given area under curve calculation can be explained with given input values -> 0.6336 = 0.00048*1320.

FAQ

What is Amount of drug administered given area under curve?

The Amount of drug administered given area under curve formula is defined as the product of the volume of plasma cleared of the drug per unit time to the area under the curve and is represented as D = CL*AUC or Dose = Volume of Plasma Cleared*Area Under Curve. The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time & Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.

How to calculate Amount of drug administered given area under curve?

The Amount of drug administered given area under curve formula is defined as the product of the volume of plasma cleared of the drug per unit time to the area under the curve is calculated using Dose = Volume of Plasma Cleared*Area Under Curve. To calculate Amount of drug administered given area under curve, you need Volume of Plasma Cleared (CL) & Area Under Curve (AUC). With our tool, you need to enter the respective value for Volume of Plasma Cleared & Area Under Curve and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Dose?

In this formula, Dose uses Volume of Plasma Cleared & Area Under Curve. We can use 2 other way(s) to calculate the same, which is/are as follows -

Dose = Volume of Distribution*Concentration of Drug
Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

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