Apparent Tissue Volume given Plasma Volume and Apparent Volume Calculator

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Plasma

Area under curve

Elimination Rate Constant

Isotonic Solutions

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%
✖Plasma Volume is the measurement in which a drug is distributed in blood plasma.ⓘ Plasma Volume [V_P]			+10% -10%
✖Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.ⓘ Fraction Unbound in Tissue [fu_t]			+10% -10%
✖Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.ⓘ Fraction Unbound in Plasma [fu]			+10% -10%

✖Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.ⓘ Apparent Tissue Volume given Plasma Volume and Apparent Volume [V_T]

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Formula

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Apparent Tissue Volume given Plasma Volume and Apparent Volume

Formula

`"V"_{"T"} = ("V"_{"d"}-"V"_{"P"})*("fu"_{"t"}/"fu")`

Example

`"2.828283L"=("9L"-"5L")*("0.7"/"0.99")`

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Apparent Tissue Volume given Plasma Volume and Apparent Volume Solution

STEP 0: Pre-Calculation Summary

Formula Used

Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
V_T = (V_d-V_P)*(fu_t/fu)
This formula uses 5 Variables

Variables Used

Apparent Tissue Volume - (Measured in Cubic Meter) - Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Plasma Volume - (Measured in Cubic Meter) - Plasma Volume is the measurement in which a drug is distributed in blood plasma.
Fraction Unbound in Tissue - Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.
Fraction Unbound in Plasma - Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.

STEP 1: Convert Input(s) to Base Unit

Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
Plasma Volume: 5 Liter --> 0.005 Cubic Meter (Check conversion here)
Fraction Unbound in Tissue: 0.7 --> No Conversion Required
Fraction Unbound in Plasma: 0.99 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V_T = (V_d-V_P)*(fu_t/fu) --> (0.009-0.005)*(0.7/0.99)

Evaluating ... ...

V_T = 0.00282828282828283

STEP 3: Convert Result to Output's Unit

0.00282828282828283 Cubic Meter -->2.82828282828283 Liter (Check conversion here)

FINAL ANSWER

2.82828282828283 ≈ 2.828283 Liter <-- Apparent Tissue Volume

(Calculation completed in 00.007 seconds)

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Apparent Tissue Volume given Plasma Volume and Apparent Volume

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Plasma Concentration of Constant Rate Infusion at Steady State

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Initial Concentration for Intravenous Bolus

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Apparent Tissue Volume given Plasma Volume and Apparent Volume Formula

Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
V_T = (V_d-V_P)*(fu_t/fu)

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume?

Apparent Tissue Volume given Plasma Volume and Apparent Volume calculator uses Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma) to calculate the Apparent Tissue Volume, The Apparent tissue volume given plasma volume and apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue. Apparent Tissue Volume is denoted by V_T symbol.

How to calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume using this online calculator? To use this online calculator for Apparent Tissue Volume given Plasma Volume and Apparent Volume, enter Volume of Distribution (V_d), Plasma Volume (V_P), Fraction Unbound in Tissue (fu_t) & Fraction Unbound in Plasma (fu) and hit the calculate button. Here is how the Apparent Tissue Volume given Plasma Volume and Apparent Volume calculation can be explained with given input values -> 2828.283 = (0.009-0.005)*(0.7/0.99).

FAQ

What is Apparent Tissue Volume given Plasma Volume and Apparent Volume?

The Apparent tissue volume given plasma volume and apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue and is represented as V_T = (V_d-V_P)*(fu_t/fu) or Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma). The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body, Plasma Volume is the measurement in which a drug is distributed in blood plasma, Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue & Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.

How to calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume?

The Apparent tissue volume given plasma volume and apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue is calculated using Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma). To calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume, you need Volume of Distribution (V_d), Plasma Volume (V_P), Fraction Unbound in Tissue (fu_t) & Fraction Unbound in Plasma (fu). With our tool, you need to enter the respective value for Volume of Distribution, Plasma Volume, Fraction Unbound in Tissue & Fraction Unbound in Plasma and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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