## Apparent Tissue Volume given Plasma Volume and Apparent Volume Solution

STEP 0: Pre-Calculation Summary
Formula Used
Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
VT = (Vd-VP)*(fut/fu)
This formula uses 5 Variables
Variables Used
Apparent Tissue Volume - (Measured in Cubic Meter) - Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Plasma Volume - (Measured in Cubic Meter) - Plasma Volume is the measurement in which a drug is distributed in blood plasma.
Fraction Unbound in Tissue - Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.
Fraction Unbound in Plasma - Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.
STEP 1: Convert Input(s) to Base Unit
Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion ​here)
Plasma Volume: 5 Liter --> 0.005 Cubic Meter (Check conversion ​here)
Fraction Unbound in Tissue: 0.7 --> No Conversion Required
Fraction Unbound in Plasma: 0.99 --> No Conversion Required
STEP 2: Evaluate Formula
Substituting Input Values in Formula
VT = (Vd-VP)*(fut/fu) --> (0.009-0.005)*(0.7/0.99)
Evaluating ... ...
VT = 0.00282828282828283
STEP 3: Convert Result to Output's Unit
0.00282828282828283 Cubic Meter -->2.82828282828283 Liter (Check conversion ​here)
2.82828282828283 2.828283 Liter <-- Apparent Tissue Volume
(Calculation completed in 00.004 seconds)
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K J Somaiya College of science (K J Somaiya), Mumbai
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Apparent Tissue Volume given Plasma Volume and Apparent Volume
Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
Plasma Volume of Drug given Apparent Volume
Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
Renal Clearance using Rate of Reabsorption
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Average Plasma Concentration given Peak through Fluctuation
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Lowest Plasma Concentration Given Peak through Fluctuation
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Peak Plasma Concentration Given Peak through Fluctuation
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Peak through Fluctuation
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Plasma Concentration of Constant Rate Infusion at Steady State
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Initial Concentration for Intravenous Bolus
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## Apparent Tissue Volume given Plasma Volume and Apparent Volume Formula

Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
VT = (Vd-VP)*(fut/fu)

## What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

## How to Calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume?

Apparent Tissue Volume given Plasma Volume and Apparent Volume calculator uses Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma) to calculate the Apparent Tissue Volume, The Apparent tissue volume given plasma volume and apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue. Apparent Tissue Volume is denoted by VT symbol.

How to calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume using this online calculator? To use this online calculator for Apparent Tissue Volume given Plasma Volume and Apparent Volume, enter Volume of Distribution (Vd), Plasma Volume (VP), Fraction Unbound in Tissue (fut) & Fraction Unbound in Plasma (fu) and hit the calculate button. Here is how the Apparent Tissue Volume given Plasma Volume and Apparent Volume calculation can be explained with given input values -> 2828.283 = (0.009-0.005)*(0.7/0.99).

### FAQ

What is Apparent Tissue Volume given Plasma Volume and Apparent Volume?
The Apparent tissue volume given plasma volume and apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue and is represented as VT = (Vd-VP)*(fut/fu) or Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma). The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body, Plasma Volume is the measurement in which a drug is distributed in blood plasma, Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue & Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.
How to calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume?
The Apparent tissue volume given plasma volume and apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue is calculated using Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma). To calculate Apparent Tissue Volume given Plasma Volume and Apparent Volume, you need Volume of Distribution (Vd), Plasma Volume (VP), Fraction Unbound in Tissue (fut) & Fraction Unbound in Plasma (fu). With our tool, you need to enter the respective value for Volume of Distribution, Plasma Volume, Fraction Unbound in Tissue & Fraction Unbound in Plasma and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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