STEP 0: Pre-Calculation Summary
Formula Used
Degradation Rate Constant = Initial Concentration Drug-Concentration After Some Time/Time Rate Drug
Ko = Ao-At/t
This formula uses 4 Variables
Variables Used
Degradation Rate Constant - (Measured in Second) - The Degradation Rate Constant is a parameter that describes the rate at which a drug undergoes degradation or breaks down over time.
Initial Concentration Drug - (Measured in Kilogram per Cubic Meter) - The Initial Concentration Drug is the drug at the start of the degradation process, usually at time zero. It provides the baseline concentration from which the degradation is measured.
Concentration After Some Time - (Measured in Kilogram per Cubic Meter) - The Concentration After Some Time is the concentration of the drug after a specified amount of time (t) has passed.
Time Rate Drug - (Measured in Second) - The Time Rate drug for degradation is the duration for which the drug has been degrading.
STEP 1: Convert Input(s) to Base Unit
Initial Concentration Drug: 200 Milligram per Liter --> 0.2 Kilogram per Cubic Meter (Check conversion here)
Concentration After Some Time: 125 Milligram per Liter --> 0.125 Kilogram per Cubic Meter (Check conversion here)
Time Rate Drug: 8 Hour --> 28800 Second (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
Ko = Ao-At/t --> 0.2-0.125/28800
Evaluating ... ...
Ko = 0.199995659722222
STEP 3: Convert Result to Output's Unit
0.199995659722222 Second -->2.31476458011831E-06 Day (Check conversion here)
2.31476458011831E-06 2.3E-6 Day <-- Degradation Rate Constant
(Calculation completed in 00.004 seconds)
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< 4 Drug Stability Calculators

Degradation Rate Constant = Initial Concentration Drug-Concentration After Some Time/Time Rate Drug
Shelf Life for Zero Order
T10 Concentration = Initial Concentration Drug/10*Degradation Rate Constant
Acceleration Factor
Acceleration Factor = Time in Field/Time in test
Shelf Life for First Order
T10 Concentration = 0.105/Initial Concentration Drug

Degradation Rate Constant = Initial Concentration Drug-Concentration After Some Time/Time Rate Drug
Ko = Ao-At/t

It is refer to refers to the speed at which the drug concentration decreases over time due to degradation. It's represented as the change in drug concentration per unit of time. In first-order kinetics, the rate of degradation is proportional to the concentration of the drug.

How to Calculate Degradation Rate Constant?

Degradation Rate Constant calculator uses Degradation Rate Constant = Initial Concentration Drug-Concentration After Some Time/Time Rate Drug to calculate the Degradation Rate Constant, The Degradation Rate Constant formula is defined as the parameter that describes the rate at which a drug undergoes degradation or breaks down over time. It is a constant value specific to the drug and the conditions under which it is stored. The units of the degradation rate constant depend on the order of the reaction and the units of concentration used. Degradation Rate Constant is denoted by Ko symbol.

How to calculate Degradation Rate Constant using this online calculator? To use this online calculator for Degradation Rate Constant, enter Initial Concentration Drug (Ao), Concentration After Some Time (At) & Time Rate Drug (t) and hit the calculate button. Here is how the Degradation Rate Constant calculation can be explained with given input values -> 2.7E-11 = 0.2-0.125/28800.