Apparent Volume of Drug Distribution Calculator

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Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Dose is the amount of drug administered.ⓘ Dose [D]			+10% -10%
✖Concentration of Drug is the amount of the drug in a given volume of plasma.ⓘ Concentration of Drug [C_ss]			+10% -10%

✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Apparent Volume of Drug Distribution [V_d]

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Formula

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Apparent Volume of Drug Distribution

Formula

`"V"_{"d"} = "D"/"C"_{"ss"}`

Example

`"0.096038L"="8mol"/"83.3mol/L"`

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Apparent Volume of Drug Distribution Solution

STEP 0: Pre-Calculation Summary

Formula Used

Volume of Distribution = Dose/Concentration of Drug
V_d = D/C_ss
This formula uses 3 Variables

Variables Used

Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Concentration of Drug - (Measured in Mole per Cubic Meter) - Concentration of Drug is the amount of the drug in a given volume of plasma.

STEP 1: Convert Input(s) to Base Unit

Dose: 8 Mole --> 8 Mole No Conversion Required
Concentration of Drug: 83.3 Mole per Liter --> 83300 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V_d = D/C_ss --> 8/83300

Evaluating ... ...

V_d = 9.60384153661465E-05

STEP 3: Convert Result to Output's Unit

9.60384153661465E-05 Cubic Meter -->0.0960384153661465 Liter (Check conversion here)

FINAL ANSWER

0.0960384153661465 ≈ 0.096038 Liter <-- Volume of Distribution

(Calculation completed in 00.004 seconds)

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Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

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< 25 Drug Content Calculators

Saponification value

Go Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken

Fraction of Drug Unbound in Tissue given Apparent Tissue Volume

Go Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)

Secretion Rate of Drug

Go Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)

Reabsorption Rate of Drug

Go Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)

Filtration Rate of Drug

Go Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)

Relative Bioavailability of Drug

Go Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)

Acid Value of KOH

Go Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken

Drug Purity given Rate of Administration and Dosing Interval

Go Drug Purity = (Drug Rate*Dosing Interval)/(Administered Dose*Bioavailability)

Rate of Administration of Drug given Dosing Interval

Go Drug Rate = (Administered Dose*Bioavailability*Drug Purity)/Dosing Interval

Drug Purity given Administrative Dose and Effective Dose

Go Drug Purity = Effective Dose/(Administered Dose*Bioavailability)

Drug Loading Efficiency

Go Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100

Encapsulation Efficiency

Go Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100

Renal Clearance of Drug

Go Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve

Concentration of Drug given Rate of Infusion of Drug

Go Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared

Rate of Infusion of Drug

Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug

Median Lethal Dose using Therapeutic Index

Go Median Lethal Dose = (Median Effective Dose*Therapeutic Index)

Margin of Safety of Drugs

Go Margin of Safety = Toxic Dose Response/Effective Dose Response

Effective Dose using Therapeutic Index

Go Median Effective Dose = Median Lethal Dose/Therapeutic Index

Therapeutic Index

Go Therapeutic Index = Median Lethal Dose/Median Effective Dose

Absorption Half-Life of Drug

Go Absorption Half Life = ln(2)/Absorption Rate Constant

Drug Rate Entering Body

Go Absorption Rate Constant = ln(2)/Absorption Half Life

Concentration of Drug using Volume of Distribution

Go Concentration of Drug = Dose/Volume of Distribution

Apparent Volume of Drug Distribution

Go Volume of Distribution = Dose/Concentration of Drug

Tablet Dosage

Go Number of tablet = Desired dosage/Stock strength

Easter Value

Go Easter Value = Saponification Value-Acid Value

Apparent Volume of Drug Distribution Formula

Volume of Distribution = Dose/Concentration of Drug
V_d = D/C_ss

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Apparent Volume of Drug Distribution?

Apparent Volume of Drug Distribution calculator uses Volume of Distribution = Dose/Concentration of Drug to calculate the Volume of Distribution, The Apparent volume of drug distribution formula is defined as the ratio of amount of drug administered to the concentration of drug. Volume of Distribution is denoted by V_d symbol.

How to calculate Apparent Volume of Drug Distribution using this online calculator? To use this online calculator for Apparent Volume of Drug Distribution, enter Dose (D) & Concentration of Drug (C_ss) and hit the calculate button. Here is how the Apparent Volume of Drug Distribution calculation can be explained with given input values -> 96.03842 = 8/83300.

FAQ

What is Apparent Volume of Drug Distribution?

The Apparent volume of drug distribution formula is defined as the ratio of amount of drug administered to the concentration of drug and is represented as V_d = D/C_ss or Volume of Distribution = Dose/Concentration of Drug. The Dose is the amount of drug administered & Concentration of Drug is the amount of the drug in a given volume of plasma.

How to calculate Apparent Volume of Drug Distribution?

The Apparent volume of drug distribution formula is defined as the ratio of amount of drug administered to the concentration of drug is calculated using Volume of Distribution = Dose/Concentration of Drug. To calculate Apparent Volume of Drug Distribution, you need Dose (D) & Concentration of Drug (C_ss). With our tool, you need to enter the respective value for Dose & Concentration of Drug and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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