Rate of Infusion of Drug Calculator

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Drug Content

Area under curve

Bioavailability

Dose

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared [CL]			+10% -10%
✖Concentration of Drug is the amount of the drug in a given volume of plasma.ⓘ Concentration of Drug [C_ss]			+10% -10%

✖The Rate of Infusion is defined as the rate required to balance elimination.ⓘ Rate of Infusion of Drug [k_in]

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Formula

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Rate of Infusion of Drug

Formula

`"k"_{"in"} = "CL"*"C"_{"ss"}`

Example

`"39.984mol/s"="0.48L/s"*"83.3mol/L"`

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Rate of Infusion of Drug Solution

STEP 0: Pre-Calculation Summary

Formula Used

Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug
k_in = CL*C_ss
This formula uses 3 Variables

Variables Used

Rate of Infusion - (Measured in Mole per Second) - The Rate of Infusion is defined as the rate required to balance elimination.
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.
Concentration of Drug - (Measured in Mole per Cubic Meter) - Concentration of Drug is the amount of the drug in a given volume of plasma.

STEP 1: Convert Input(s) to Base Unit

Volume of Plasma Cleared: 0.48 Liter per Second --> 0.00048 Cubic Meter per Second (Check conversion here)
Concentration of Drug: 83.3 Mole per Liter --> 83300 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

k_in = CL*C_ss --> 0.00048*83300

Evaluating ... ...

k_in = 39.984

STEP 3: Convert Result to Output's Unit

39.984 Mole per Second --> No Conversion Required

FINAL ANSWER

39.984 Mole per Second <-- Rate of Infusion

(Calculation completed in 00.004 seconds)

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Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

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Go Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken

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Go Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)

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Go Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)

Reabsorption Rate of Drug

Go Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)

Filtration Rate of Drug

Go Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)

Relative Bioavailability of Drug

Go Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)

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Go Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken

Drug Purity given Rate of Administration and Dosing Interval

Go Drug Purity = (Drug Rate*Dosing Interval)/(Administered Dose*Bioavailability)

Rate of Administration of Drug given Dosing Interval

Go Drug Rate = (Administered Dose*Bioavailability*Drug Purity)/Dosing Interval

Drug Purity given Administrative Dose and Effective Dose

Go Drug Purity = Effective Dose/(Administered Dose*Bioavailability)

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Go Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100

Encapsulation Efficiency

Go Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100

Renal Clearance of Drug

Go Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve

Concentration of Drug given Rate of Infusion of Drug

Go Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared

Rate of Infusion of Drug

Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug

Median Lethal Dose using Therapeutic Index

Go Median Lethal Dose = (Median Effective Dose*Therapeutic Index)

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Go Margin of Safety = Toxic Dose Response/Effective Dose Response

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Go Median Effective Dose = Median Lethal Dose/Therapeutic Index

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Go Therapeutic Index = Median Lethal Dose/Median Effective Dose

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Go Absorption Half Life = ln(2)/Absorption Rate Constant

Drug Rate Entering Body

Go Absorption Rate Constant = ln(2)/Absorption Half Life

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Go Concentration of Drug = Dose/Volume of Distribution

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Go Volume of Distribution = Dose/Concentration of Drug

Tablet Dosage

Go Number of tablet = Desired dosage/Stock strength

Easter Value

Go Easter Value = Saponification Value-Acid Value

Rate of Infusion of Drug Formula

Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug
k_in = CL*C_ss

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Rate of Infusion of Drug?

Rate of Infusion of Drug calculator uses Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug to calculate the Rate of Infusion, The Rate of infusion of drug formula is defined as the product of amount of drug in a given volume of plasma to the volume of plasma cleared of the drug per unit time. Rate of Infusion is denoted by k_in symbol.

How to calculate Rate of Infusion of Drug using this online calculator? To use this online calculator for Rate of Infusion of Drug, enter Volume of Plasma Cleared (CL) & Concentration of Drug (C_ss) and hit the calculate button. Here is how the Rate of Infusion of Drug calculation can be explained with given input values -> 39.984 = 0.00048*83300.

FAQ

What is Rate of Infusion of Drug?

The Rate of infusion of drug formula is defined as the product of amount of drug in a given volume of plasma to the volume of plasma cleared of the drug per unit time and is represented as k_in = CL*C_ss or Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug. The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time & Concentration of Drug is the amount of the drug in a given volume of plasma.

How to calculate Rate of Infusion of Drug?

The Rate of infusion of drug formula is defined as the product of amount of drug in a given volume of plasma to the volume of plasma cleared of the drug per unit time is calculated using Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug. To calculate Rate of Infusion of Drug, you need Volume of Plasma Cleared (CL) & Concentration of Drug (C_ss). With our tool, you need to enter the respective value for Volume of Plasma Cleared & Concentration of Drug and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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