Bioavailability of Drug given Maintenance Dose Solution

STEP 0: Pre-Calculation Summary
Formula Used
Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose
F% = (CLdrug*Cp)/MD
This formula uses 4 Variables
Variables Used
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.
Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
STEP 1: Convert Input(s) to Base Unit
Drug Clearance: 2 Cubic Meter per Second --> 2 Cubic Meter per Second No Conversion Required
Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion ​here)
Maintenance Dose: 70 Milligram per Hour --> 1.94444444444444E-08 Kilogram per Second (Check conversion ​here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
F% = (CLdrug*Cp)/MD --> (2*0.03)/1.94444444444444E-08
Evaluating ... ...
F% = 3085714.28571429
STEP 3: Convert Result to Output's Unit
3085714.28571429 --> No Conversion Required
FINAL ANSWER
3085714.28571429 3.1E+6 <-- Bioavailability Of drug dose
(Calculation completed in 00.004 seconds)

Credits

Creator Image
Created by Ritacheta Sen
University of Calcutta (C.U), Kolkata
Ritacheta Sen has created this Calculator and 25+ more calculators!
Verifier Image
Verified by Soupayan banerjee
National University of Judicial Science (NUJS), Kolkata
Soupayan banerjee has verified this Calculator and 800+ more calculators!

25 Dose Calculators

Dose of drug administered orally
​ Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)
Dose of drug administered intravenous
​ Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous
Dose of A type drug
​ Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)
Dose of B type drug
​ Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)
Administrative dose given rate of administration and dosing interval
​ Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)
Previous Rate of Drug Dose given Revised Dose
​ Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)
Dosing interval given rate of administration
​ Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration
Revised Dose
​ Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma
Loading Dose
​ Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose
Maintenance Dose
​ Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose
Dose given volume of distribution and area under curve
​ Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve
Administrative Dose given Drug Purity
​ Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)
Effective dose given drug purity
​ Go Effective Dose = Drug Purity*Bioavailability*Administered Dose
Adult Dose of Drug by Clark's Equation in Micrograms
​ Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)
Clark's Equation of Dosage in Microgram
​ Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)
Dosing interval given average plasma concentration
​ Go Dosing Interval = Area Under Curve/Average Plasma Concentration
Adult Dose of Drug by Clark's Equation
​ Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)
Weight of Patient by Clark's equation
​ Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150
Clark's Equation of Dosage
​ Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)
Weight of Patient in Kilograms by Clark's equation
​ Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68
Amount of drug administered given apparent volume
​ Go Dose = Volume of Distribution*Concentration of Drug
Amount of drug in given volume of plasma
​ Go Concentration of Drug = Dose/Volume of Distribution
Administrative dose given effective dose and bioavailability
​ Go Administered Dose = Effective Dose/Bioavailability
Effective dose given bioavailability and administrative dose
​ Go Effective Dose = Bioavailability*Administered Dose
Amount of drug administered given area under curve
​ Go Dose = Volume of Plasma Cleared*Area Under Curve

Bioavailability of Drug given Maintenance Dose Formula

Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose
F% = (CLdrug*Cp)/MD

What is the bioavailability for intravenous drug?

For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.

How to Calculate Bioavailability of Drug given Maintenance Dose?

Bioavailability of Drug given Maintenance Dose calculator uses Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose to calculate the Bioavailability Of drug dose, The Bioavailability of Drug given Maintenance Dose formula is defined as the ratio of the product of the clearance of drug and target plasma concentration to the maintenance dose. Bioavailability Of drug dose is denoted by F% symbol.

How to calculate Bioavailability of Drug given Maintenance Dose using this online calculator? To use this online calculator for Bioavailability of Drug given Maintenance Dose, enter Drug Clearance (CLdrug), Target Plasma Concentration (Cp) & Maintenance Dose (MD) and hit the calculate button. Here is how the Bioavailability of Drug given Maintenance Dose calculation can be explained with given input values -> 3.1E+6 = (2*0.03)/1.94444444444444E-08.

FAQ

What is Bioavailability of Drug given Maintenance Dose?
The Bioavailability of Drug given Maintenance Dose formula is defined as the ratio of the product of the clearance of drug and target plasma concentration to the maintenance dose and is represented as F% = (CLdrug*Cp)/MD or Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose. Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation, The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration & The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
How to calculate Bioavailability of Drug given Maintenance Dose?
The Bioavailability of Drug given Maintenance Dose formula is defined as the ratio of the product of the clearance of drug and target plasma concentration to the maintenance dose is calculated using Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose. To calculate Bioavailability of Drug given Maintenance Dose, you need Drug Clearance (CLdrug), Target Plasma Concentration (Cp) & Maintenance Dose (MD). With our tool, you need to enter the respective value for Drug Clearance, Target Plasma Concentration & Maintenance Dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
How many ways are there to calculate Bioavailability Of drug dose?
In this formula, Bioavailability Of drug dose uses Drug Clearance, Target Plasma Concentration & Maintenance Dose. We can use 1 other way(s) to calculate the same, which is/are as follows -
  • Bioavailability Of drug dose = (Volume Of Distribution dose*Target Plasma Concentration)/Loading Dose
Let Others Know
Facebook
Twitter
Reddit
LinkedIn
Email
WhatsApp
Copied!