Clearance of Drug given Maintenance Dose Calculator

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Dose

Area under curve

Bioavailability

Drug Content

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.ⓘ Maintenance Dose [MD]			+10% -10%
✖The Bioavailability of Drug is defined as the systemically available fraction of a drug.ⓘ Bioavailability of Drug [f]			+10% -10%
✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration [C_p]			+10% -10%

✖Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Clearance of Drug given Maintenance Dose [CL_drug]

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Formula

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Clearance of Drug given Maintenance Dose

Formula

`"CL"_{"drug"} = ("MD"*"f")/"C"_{"p"}`

Example

`"6.2E^-6m³/s"=("70mg/h"*"9.5")/"30mg/L"`

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Clearance of Drug given Maintenance Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration
CL_drug = (MD*f)/C_p
This formula uses 4 Variables

Variables Used

Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.
Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
Bioavailability of Drug - The Bioavailability of Drug is defined as the systemically available fraction of a drug.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

STEP 1: Convert Input(s) to Base Unit

Maintenance Dose: 70 Milligram per Hour --> 1.94444444444444E-08 Kilogram per Second (Check conversion here)
Bioavailability of Drug: 9.5 --> No Conversion Required
Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

CL_drug = (MD*f)/C_p --> (1.94444444444444E-08*9.5)/0.03

Evaluating ... ...

CL_drug = 6.15740740740739E-06

STEP 3: Convert Result to Output's Unit

6.15740740740739E-06 Cubic Meter per Second --> No Conversion Required

FINAL ANSWER

6.15740740740739E-06 ≈ 6.2E-6 Cubic Meter per Second <-- Drug Clearance

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Clearance of Drug given Maintenance Dose Formula

Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration
CL_drug = (MD*f)/C_p

How does maintenance dose help in therapy ?

Maintenance dose is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with dose regimen, which is a type of drug therapy in which the dose [mg] of a drug is given at a regular dosing interval on a repetitive basis. Continuing the maintenance dose for about 4 to 5 half-lives (t½) of the drug will approximate the steady state level. One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a loading dose.

How to Calculate Clearance of Drug given Maintenance Dose?

Clearance of Drug given Maintenance Dose calculator uses Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration to calculate the Drug Clearance, The Clearance of Drug given Maintenance Dose formula is defined as ratio of the product of the maintenance dose and bioavailability of drug to the target plasma concentration. Drug Clearance is denoted by CL_drug symbol.

How to calculate Clearance of Drug given Maintenance Dose using this online calculator? To use this online calculator for Clearance of Drug given Maintenance Dose, enter Maintenance Dose (MD), Bioavailability of Drug (f) & Target Plasma Concentration (C_p) and hit the calculate button. Here is how the Clearance of Drug given Maintenance Dose calculation can be explained with given input values -> 6.2E-6 = (1.94444444444444E-08*9.5)/0.03.

FAQ

What is Clearance of Drug given Maintenance Dose?

The Clearance of Drug given Maintenance Dose formula is defined as ratio of the product of the maintenance dose and bioavailability of drug to the target plasma concentration and is represented as CL_drug = (MD*f)/C_p or Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration. The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration, The Bioavailability of Drug is defined as the systemically available fraction of a drug & The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

How to calculate Clearance of Drug given Maintenance Dose?

The Clearance of Drug given Maintenance Dose formula is defined as ratio of the product of the maintenance dose and bioavailability of drug to the target plasma concentration is calculated using Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration. To calculate Clearance of Drug given Maintenance Dose, you need Maintenance Dose (MD), Bioavailability of Drug (f) & Target Plasma Concentration (C_p). With our tool, you need to enter the respective value for Maintenance Dose, Bioavailability of Drug & Target Plasma Concentration and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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