Concentration of Drug using Volume of Distribution Calculator

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Drug Content

Area under curve

Bioavailability

Dose

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Dose is the amount of drug administered.ⓘ Dose [D]			+10% -10%
✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%

✖Concentration of Drug is the amount of the drug in a given volume of plasma.ⓘ Concentration of Drug using Volume of Distribution [C_ss]

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Formula

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Concentration of Drug using Volume of Distribution

Formula

`"C"_{"ss"} = "D"/"V"_{"d"}`

Example

`"0.888889mol/L"="8mol"/"9L"`

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Concentration of Drug using Volume of Distribution Solution

STEP 0: Pre-Calculation Summary

Formula Used

Concentration of Drug = Dose/Volume of Distribution
C_ss = D/V_d
This formula uses 3 Variables

Variables Used

Concentration of Drug - (Measured in Mole per Cubic Meter) - Concentration of Drug is the amount of the drug in a given volume of plasma.
Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

STEP 1: Convert Input(s) to Base Unit

Dose: 8 Mole --> 8 Mole No Conversion Required
Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

C_ss = D/V_d --> 8/0.009

Evaluating ... ...

C_ss = 888.888888888889

STEP 3: Convert Result to Output's Unit

888.888888888889 Mole per Cubic Meter -->0.888888888888889 Mole per Liter (Check conversion here)

FINAL ANSWER

0.888888888888889 ≈ 0.888889 Mole per Liter <-- Concentration of Drug

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

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Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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< 25 Drug Content Calculators

Saponification value

Go Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken

Fraction of Drug Unbound in Tissue given Apparent Tissue Volume

Go Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)

Secretion Rate of Drug

Go Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)

Reabsorption Rate of Drug

Go Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)

Filtration Rate of Drug

Go Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)

Relative Bioavailability of Drug

Go Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)

Acid Value of KOH

Go Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken

Drug Purity given Rate of Administration and Dosing Interval

Go Drug Purity = (Drug Rate*Dosing Interval)/(Administered Dose*Bioavailability)

Rate of Administration of Drug given Dosing Interval

Go Drug Rate = (Administered Dose*Bioavailability*Drug Purity)/Dosing Interval

Drug Purity given Administrative Dose and Effective Dose

Go Drug Purity = Effective Dose/(Administered Dose*Bioavailability)

Drug Loading Efficiency

Go Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100

Encapsulation Efficiency

Go Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100

Renal Clearance of Drug

Go Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve

Concentration of Drug given Rate of Infusion of Drug

Go Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared

Rate of Infusion of Drug

Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug

Median Lethal Dose using Therapeutic Index

Go Median Lethal Dose = (Median Effective Dose*Therapeutic Index)

Margin of Safety of Drugs

Go Margin of Safety = Toxic Dose Response/Effective Dose Response

Effective Dose using Therapeutic Index

Go Median Effective Dose = Median Lethal Dose/Therapeutic Index

Therapeutic Index

Go Therapeutic Index = Median Lethal Dose/Median Effective Dose

Absorption Half-Life of Drug

Go Absorption Half Life = ln(2)/Absorption Rate Constant

Drug Rate Entering Body

Go Absorption Rate Constant = ln(2)/Absorption Half Life

Concentration of Drug using Volume of Distribution

Go Concentration of Drug = Dose/Volume of Distribution

Apparent Volume of Drug Distribution

Go Volume of Distribution = Dose/Concentration of Drug

Tablet Dosage

Go Number of tablet = Desired dosage/Stock strength

Easter Value

Go Easter Value = Saponification Value-Acid Value

Concentration of Drug using Volume of Distribution Formula

Concentration of Drug = Dose/Volume of Distribution
C_ss = D/V_d

What is the main application of pharmacokinetics ?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Concentration of Drug using Volume of Distribution?

Concentration of Drug using Volume of Distribution calculator uses Concentration of Drug = Dose/Volume of Distribution to calculate the Concentration of Drug, The Concentration of Drug Using Volume of Distribution formula is defined as the ratio of the amount of drug administered to the apparent volume of drug distribution. Concentration of Drug is denoted by C_ss symbol.

How to calculate Concentration of Drug using Volume of Distribution using this online calculator? To use this online calculator for Concentration of Drug using Volume of Distribution, enter Dose (D) & Volume of Distribution (V_d) and hit the calculate button. Here is how the Concentration of Drug using Volume of Distribution calculation can be explained with given input values -> 0.000889 = 8/0.009.

FAQ

What is Concentration of Drug using Volume of Distribution?

The Concentration of Drug Using Volume of Distribution formula is defined as the ratio of the amount of drug administered to the apparent volume of drug distribution and is represented as C_ss = D/V_d or Concentration of Drug = Dose/Volume of Distribution. The Dose is the amount of drug administered & The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

How to calculate Concentration of Drug using Volume of Distribution?

The Concentration of Drug Using Volume of Distribution formula is defined as the ratio of the amount of drug administered to the apparent volume of drug distribution is calculated using Concentration of Drug = Dose/Volume of Distribution. To calculate Concentration of Drug using Volume of Distribution, you need Dose (D) & Volume of Distribution (V_d). With our tool, you need to enter the respective value for Dose & Volume of Distribution and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Concentration of Drug?

In this formula, Concentration of Drug uses Dose & Volume of Distribution. We can use 1 other way(s) to calculate the same, which is/are as follows -

Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared

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