Dose of B type drug Calculator

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Elimination Rate Constant

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Volume of Distribution

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✖Relative Bioavailability compares the bioavailability between two different dosage forms.ⓘ Relative Bioavailability [F_rel]			+10% -10%
✖Dose Type A is the amount of drug administered in A-type dosage form.ⓘ Dose Type A [D_A]			+10% -10%
✖The Area under curve Dosage B is the integral of the concentration-time curve for B form of dosage.ⓘ Area under curve Dosage B [AUC_dosageB]			+10% -10%
✖The Area under curve Dosage A is the integral of the concentration-time curve for A form of dosage.ⓘ Area under curve Dosage A [AUC_dosageA]			+10% -10%

✖Dose Type B is the amount of drug administered in B-type dosage form.ⓘ Dose of B type drug [D_B]

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Formula

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Dose of B type drug

Formula

`"D"_{"B"} = ("F"_{"rel"}*"D"_{"A"})*("AUC"_{"dosageB"}/"AUC"_{"dosageA"})`

Example

`"15.71096mol"=("0.9"*"11.5mol")*("1.732mol*s/L"/"1.141mol*s/L")`

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Dose of B type drug Solution

STEP 0: Pre-Calculation Summary

Formula Used

Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)
D_B = (F_rel*D_A)*(AUC_dosageB/AUC_dosageA)
This formula uses 5 Variables

Variables Used

Dose Type B - (Measured in Mole) - Dose Type B is the amount of drug administered in B-type dosage form.
Relative Bioavailability - Relative Bioavailability compares the bioavailability between two different dosage forms.
Dose Type A - (Measured in Mole) - Dose Type A is the amount of drug administered in A-type dosage form.
Area under curve Dosage B - (Measured in Mole Second per Cubic Meter) - The Area under curve Dosage B is the integral of the concentration-time curve for B form of dosage.
Area under curve Dosage A - (Measured in Mole Second per Cubic Meter) - The Area under curve Dosage A is the integral of the concentration-time curve for A form of dosage.

STEP 1: Convert Input(s) to Base Unit

Relative Bioavailability: 0.9 --> No Conversion Required
Dose Type A: 11.5 Mole --> 11.5 Mole No Conversion Required
Area under curve Dosage B: 1.732 Mole Second per Liter --> 1732 Mole Second per Cubic Meter (Check conversion here)
Area under curve Dosage A: 1.141 Mole Second per Liter --> 1141 Mole Second per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

D_B = (F_rel*D_A)*(AUC_dosageB/AUC_dosageA) --> (0.9*11.5)*(1732/1141)

Evaluating ... ...

D_B = 15.7109553023663

STEP 3: Convert Result to Output's Unit

15.7109553023663 Mole --> No Conversion Required

FINAL ANSWER

15.7109553023663 ≈ 15.71096 Mole <-- Dose Type B

(Calculation completed in 00.004 seconds)

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Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

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University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Dose of B type drug Formula

Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)
D_B = (F_rel*D_A)*(AUC_dosageB/AUC_dosageA)

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Dose of B type drug?

Dose of B type drug calculator uses Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A) to calculate the Dose Type B, The Dose of B type drug formula is defined as the comparison of the bioavailability between two different dosage forms. The relative AUCs are used to make this comparison and relative doses are used to normalize the calculation. Dose Type B is denoted by D_B symbol.

How to calculate Dose of B type drug using this online calculator? To use this online calculator for Dose of B type drug, enter Relative Bioavailability (F_rel), Dose Type A (D_A), Area under curve Dosage B (AUC_dosageB) & Area under curve Dosage A (AUC_dosageA) and hit the calculate button. Here is how the Dose of B type drug calculation can be explained with given input values -> 15.71096 = (0.9*11.5)*(1732/1141).

FAQ

What is Dose of B type drug?

The Dose of B type drug formula is defined as the comparison of the bioavailability between two different dosage forms. The relative AUCs are used to make this comparison and relative doses are used to normalize the calculation and is represented as D_B = (F_rel*D_A)*(AUC_dosageB/AUC_dosageA) or Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A). Relative Bioavailability compares the bioavailability between two different dosage forms, Dose Type A is the amount of drug administered in A-type dosage form, The Area under curve Dosage B is the integral of the concentration-time curve for B form of dosage & The Area under curve Dosage A is the integral of the concentration-time curve for A form of dosage.

How to calculate Dose of B type drug?

The Dose of B type drug formula is defined as the comparison of the bioavailability between two different dosage forms. The relative AUCs are used to make this comparison and relative doses are used to normalize the calculation is calculated using Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A). To calculate Dose of B type drug, you need Relative Bioavailability (F_rel), Dose Type A (D_A), Area under curve Dosage B (AUC_dosageB) & Area under curve Dosage A (AUC_dosageA). With our tool, you need to enter the respective value for Relative Bioavailability, Dose Type A, Area under curve Dosage B & Area under curve Dosage A and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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