Dose of drug administered orally Calculator

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Dose

Area under curve

Bioavailability

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Elimination Rate Constant

Isotonic Solutions

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Volume of Distribution

Volume of plasma cleared

✖The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally.ⓘ Area under Curve Non-Intravenous [AUC_po]			+10% -10%
✖The Dose Intravenous is the amount of drug administered intravenously.ⓘ Dose Intravenous [D_iv]			+10% -10%
✖Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous.ⓘ Area under Curve Intravenous [AUC_iv]			+10% -10%
✖The Bioavailability of Drug is defined as the systemically available fraction of a drug.ⓘ Bioavailability of Drug [f]			+10% -10%

✖The Dose Non-Intravenous is the amount of drug administered orally.ⓘ Dose of drug administered orally [D_po]

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Formula

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Dose of drug administered orally

Formula

`"D"_{"po"} = ("AUC"_{"po"}*"D"_{"iv"})/("AUC"_{"iv"}*"f")`

Example

`"0.688995mol"=("6mol*s/L"*"12mol")/("11mol*s/L"*"9.5")`

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Dose of drug administered orally Solution

STEP 0: Pre-Calculation Summary

Formula Used

Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)
D_po = (AUC_po*D_iv)/(AUC_iv*f)
This formula uses 5 Variables

Variables Used

Dose Non-Intravenous - (Measured in Mole) - The Dose Non-Intravenous is the amount of drug administered orally.
Area under Curve Non-Intravenous - (Measured in Mole Second per Cubic Meter) - The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally.
Dose Intravenous - (Measured in Mole) - The Dose Intravenous is the amount of drug administered intravenously.
Area under Curve Intravenous - (Measured in Mole Second per Cubic Meter) - Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous.
Bioavailability of Drug - The Bioavailability of Drug is defined as the systemically available fraction of a drug.

STEP 1: Convert Input(s) to Base Unit

Area under Curve Non-Intravenous: 6 Mole Second per Liter --> 6000 Mole Second per Cubic Meter (Check conversion here)
Dose Intravenous: 12 Mole --> 12 Mole No Conversion Required
Area under Curve Intravenous: 11 Mole Second per Liter --> 11000 Mole Second per Cubic Meter (Check conversion here)
Bioavailability of Drug: 9.5 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

D_po = (AUC_po*D_iv)/(AUC_iv*f) --> (6000*12)/(11000*9.5)

Evaluating ... ...

D_po = 0.688995215311005

STEP 3: Convert Result to Output's Unit

0.688995215311005 Mole --> No Conversion Required

FINAL ANSWER

0.688995215311005 ≈ 0.688995 Mole <-- Dose Non-Intravenous

(Calculation completed in 00.004 seconds)

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Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Dose of drug administered orally Formula

Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)
D_po = (AUC_po*D_iv)/(AUC_iv*f)

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Dose of drug administered orally?

Dose of drug administered orally calculator uses Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug) to calculate the Dose Non-Intravenous, The Dose of drug administered orally formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration. Dose Non-Intravenous is denoted by D_po symbol.

How to calculate Dose of drug administered orally using this online calculator? To use this online calculator for Dose of drug administered orally, enter Area under Curve Non-Intravenous (AUC_po), Dose Intravenous (D_iv), Area under Curve Intravenous (AUC_iv) & Bioavailability of Drug (f) and hit the calculate button. Here is how the Dose of drug administered orally calculation can be explained with given input values -> 0.688995 = (6000*12)/(11000*9.5).

FAQ

What is Dose of drug administered orally?

The Dose of drug administered orally formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration and is represented as D_po = (AUC_po*D_iv)/(AUC_iv*f) or Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug). The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally, The Dose Intravenous is the amount of drug administered intravenously, Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous & The Bioavailability of Drug is defined as the systemically available fraction of a drug.

How to calculate Dose of drug administered orally?

The Dose of drug administered orally formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration is calculated using Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug). To calculate Dose of drug administered orally, you need Area under Curve Non-Intravenous (AUC_po), Dose Intravenous (D_iv), Area under Curve Intravenous (AUC_iv) & Bioavailability of Drug (f). With our tool, you need to enter the respective value for Area under Curve Non-Intravenous, Dose Intravenous, Area under Curve Intravenous & Bioavailability of Drug and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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