Dose of Drug given Volume of Distribution Calculator

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✖Concentration of Drug is the amount of the drug in a given volume of plasma.ⓘ Concentration of Drug [C_ss]			+10% -10%
✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%

✖The Dose is the amount of drug administered.ⓘ Dose of Drug given Volume of Distribution [D]

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Formula

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Dose of Drug given Volume of Distribution

Formula

`"D" = "C"_{"ss"}*"V"_{"d"}`

Example

`"749.7mol"="83.3mol/L"*"9L"`

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Dose of Drug given Volume of Distribution Solution

STEP 0: Pre-Calculation Summary

Formula Used

Dose = Concentration of Drug*Volume of Distribution
D = C_ss*V_d
This formula uses 3 Variables

Variables Used

Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Concentration of Drug - (Measured in Mole per Cubic Meter) - Concentration of Drug is the amount of the drug in a given volume of plasma.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

STEP 1: Convert Input(s) to Base Unit

Concentration of Drug: 83.3 Mole per Liter --> 83300 Mole per Cubic Meter (Check conversion here)
Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

D = C_ss*V_d --> 83300*0.009

Evaluating ... ...

D = 749.7

STEP 3: Convert Result to Output's Unit

749.7 Mole --> No Conversion Required

FINAL ANSWER

749.7 Mole <-- Dose

(Calculation completed in 00.020 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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Saponification value

Go Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken

Fraction of Drug Unbound in Tissue given Apparent Tissue Volume

Go Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)

Secretion Rate of Drug

Go Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)

Reabsorption Rate of Drug

Go Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)

Filtration Rate of Drug

Go Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)

Relative Bioavailability of Drug

Go Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)

Acid Value of KOH

Go Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken

Drug Purity given Rate of Administration and Dosing Interval

Go Drug Purity = (Drug Rate*Dosing Interval)/(Administered Dose*Bioavailability)

Rate of Administration of Drug given Dosing Interval

Go Drug Rate = (Administered Dose*Bioavailability*Drug Purity)/Dosing Interval

Drug Purity given Administrative Dose and Effective Dose

Go Drug Purity = Effective Dose/(Administered Dose*Bioavailability)

Drug Loading Efficiency

Go Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100

Encapsulation Efficiency

Go Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100

Renal Clearance of Drug

Go Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve

Concentration of Drug given Rate of Infusion of Drug

Go Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared

Rate of Infusion of Drug

Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug

Median Lethal Dose using Therapeutic Index

Go Median Lethal Dose = (Median Effective Dose*Therapeutic Index)

Margin of Safety of Drugs

Go Margin of Safety = Toxic Dose Response/Effective Dose Response

Effective Dose using Therapeutic Index

Go Median Effective Dose = Median Lethal Dose/Therapeutic Index

Therapeutic Index

Go Therapeutic Index = Median Lethal Dose/Median Effective Dose

Absorption Half-Life of Drug

Go Absorption Half Life = ln(2)/Absorption Rate Constant

Drug Rate Entering Body

Go Absorption Rate Constant = ln(2)/Absorption Half Life

Concentration of Drug using Volume of Distribution

Go Concentration of Drug = Dose/Volume of Distribution

Apparent Volume of Drug Distribution

Go Volume of Distribution = Dose/Concentration of Drug

Tablet Dosage

Go Number of tablet = Desired dosage/Stock strength

Easter Value

Go Easter Value = Saponification Value-Acid Value

Dose of Drug given Volume of Distribution Formula

Dose = Concentration of Drug*Volume of Distribution
D = C_ss*V_d

What is elimination phase in pharmacokinetics ?

A drug obeys one-compartment kinetics and is delivered via a rapid IV injection. Then, the decrease in the concentration of drug in the plasma might be due to eliminating drug through the body (not via the distribution). Therefore this phase is also termed the elimination phase in pharmacokinetics.

How to Calculate Dose of Drug given Volume of Distribution?

Dose of Drug given Volume of Distribution calculator uses Dose = Concentration of Drug*Volume of Distribution to calculate the Dose, The Dose of Drug given Volume of Distribution formula is defined as the product of the concentration of the drug and the volume of distribution of the drug. Dose is denoted by D symbol.

How to calculate Dose of Drug given Volume of Distribution using this online calculator? To use this online calculator for Dose of Drug given Volume of Distribution, enter Concentration of Drug (C_ss) & Volume of Distribution (V_d) and hit the calculate button. Here is how the Dose of Drug given Volume of Distribution calculation can be explained with given input values -> 749.7 = 83300*0.009.

FAQ

What is Dose of Drug given Volume of Distribution?

The Dose of Drug given Volume of Distribution formula is defined as the product of the concentration of the drug and the volume of distribution of the drug and is represented as D = C_ss*V_d or Dose = Concentration of Drug*Volume of Distribution. Concentration of Drug is the amount of the drug in a given volume of plasma & The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

How to calculate Dose of Drug given Volume of Distribution?

The Dose of Drug given Volume of Distribution formula is defined as the product of the concentration of the drug and the volume of distribution of the drug is calculated using Dose = Concentration of Drug*Volume of Distribution. To calculate Dose of Drug given Volume of Distribution, you need Concentration of Drug (C_ss) & Volume of Distribution (V_d). With our tool, you need to enter the respective value for Concentration of Drug & Volume of Distribution and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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