Loading Dose Calculator

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Dose

Area under curve

Bioavailability

Drug Content

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration [C_p]			+10% -10%
✖The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma.ⓘ Volume Of Distribution dose [V_d]			+10% -10%
✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability Of drug dose [F%]			+10% -10%

✖The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration.ⓘ Loading Dose [LD]

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Formula

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Loading Dose

Formula

`"LD" = ("C"_{"p"}*"V"_{"d"})/"F%"`

Example

`"1666.667mg"=("30mg/L"*"50L")/"0.9"`

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Loading Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose
LD = (C_p*V_d)/F%
This formula uses 4 Variables

Variables Used

Loading Dose - (Measured in Kilogram) - The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Volume Of Distribution dose - (Measured in Cubic Meter) - The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma.
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

STEP 1: Convert Input(s) to Base Unit

Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion here)
Volume Of Distribution dose: 50 Liter --> 0.05 Cubic Meter (Check conversion here)
Bioavailability Of drug dose: 0.9 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

LD = (C_p*V_d)/F% --> (0.03*0.05)/0.9

Evaluating ... ...

LD = 0.00166666666666667

STEP 3: Convert Result to Output's Unit

0.00166666666666667 Kilogram -->1666.66666666667 Milligram (Check conversion here)

FINAL ANSWER

1666.66666666667 ≈ 1666.667 Milligram <-- Loading Dose

(Calculation completed in 00.020 seconds)

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Created by swapnalijadhav

idealinstituteofpharmacy (iip), Maharashtra

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National University of Judicial Science (NUJS), Kolkata

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Loading Dose Formula

Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose
LD = (C_p*V_d)/F%

What is loading dose in terms of calculation?

Loading dose is defined as the Target Plasma concentration multiplied by the volume of distribution for dose of drug

How to Calculate Loading Dose?

Loading Dose calculator uses Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose to calculate the Loading Dose, The Loading dose formula is defined as the initial dose of a drug that is administered to achieve a desired plasma concentration. Loading Dose is denoted by LD symbol.

How to calculate Loading Dose using this online calculator? To use this online calculator for Loading Dose, enter Target Plasma Concentration (C_p), Volume Of Distribution dose (V_d) & Bioavailability Of drug dose (F%) and hit the calculate button. Here is how the Loading Dose calculation can be explained with given input values -> 0.001667 = (0.03*0.05)/0.9.

FAQ

What is Loading Dose?

The Loading dose formula is defined as the initial dose of a drug that is administered to achieve a desired plasma concentration and is represented as LD = (C_p*V_d)/F% or Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose. The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration, The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma & The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

How to calculate Loading Dose?

The Loading dose formula is defined as the initial dose of a drug that is administered to achieve a desired plasma concentration is calculated using Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose. To calculate Loading Dose, you need Target Plasma Concentration (C_p), Volume Of Distribution dose (V_d) & Bioavailability Of drug dose (F%). With our tool, you need to enter the respective value for Target Plasma Concentration, Volume Of Distribution dose & Bioavailability Of drug dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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