Maintenance Dose Calculator

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Dose

Area under curve

Bioavailability

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Elimination Rate Constant

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Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Drug Clearance [CL_drug]			+10% -10%
✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration [C_p]			+10% -10%
✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability Of drug dose [F%]			+10% -10%

✖The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.ⓘ Maintenance Dose [MD]

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Formula

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Maintenance Dose

Formula

`"MD" = "CL"_{"drug"}*"C"_{"p"}/"F%"`

Example

`"2.4E^8mg/h"="2m³/s"*"30mg/L"/"0.9"`

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Maintenance Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose
MD = CL_drug*C_p/F%
This formula uses 4 Variables

Variables Used

Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

STEP 1: Convert Input(s) to Base Unit

Drug Clearance: 2 Cubic Meter per Second --> 2 Cubic Meter per Second No Conversion Required
Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion here)
Bioavailability Of drug dose: 0.9 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

MD = CL_drug*C_p/F% --> 2*0.03/0.9

Evaluating ... ...

MD = 0.0666666666666667

STEP 3: Convert Result to Output's Unit

0.0666666666666667 Kilogram per Second -->240000000 Milligram per Hour (Check conversion here)

FINAL ANSWER

240000000 ≈ 2.4E+8 Milligram per Hour <-- Maintenance Dose

(Calculation completed in 00.020 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Maintenance Dose Formula

Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose
MD = CL_drug*C_p/F%

What is the maintenance dose for allergic reactions to stinging and biting?

The recommended maintenance dose is 100 μg of the venom, for both children and adults. This maintenance dose is equivalent to approximately two bee stings or several vespid stings. A higher dose (e.g., 200 μg) is recommended when systemic reactions occur after re-exposure to a field sting or a sting challenge. In highly exposed subjects such as beekeepers or professional gardeners a maintenance dose of 200 μg is advised.

How to Calculate Maintenance Dose?

Maintenance Dose calculator uses Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose to calculate the Maintenance Dose, The Maintenance Dose formula is defined as the dose of a drug that is administered on a regular basis to maintain a desired plasma concentration. Maintenance Dose is denoted by MD symbol.

How to calculate Maintenance Dose using this online calculator? To use this online calculator for Maintenance Dose, enter Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Bioavailability Of drug dose (F%) and hit the calculate button. Here is how the Maintenance Dose calculation can be explained with given input values -> 8.6E+17 = 2*0.03/0.9.

FAQ

What is Maintenance Dose?

The Maintenance Dose formula is defined as the dose of a drug that is administered on a regular basis to maintain a desired plasma concentration and is represented as MD = CL_drug*C_p/F% or Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose. Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation, The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration & The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

How to calculate Maintenance Dose?

The Maintenance Dose formula is defined as the dose of a drug that is administered on a regular basis to maintain a desired plasma concentration is calculated using Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose. To calculate Maintenance Dose, you need Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Bioavailability Of drug dose (F%). With our tool, you need to enter the respective value for Drug Clearance, Target Plasma Concentration & Bioavailability Of drug dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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