Plasma Concentration of Constant Rate Infusion at Steady State Solution

STEP 0: Pre-Calculation Summary
Formula Used
Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance
CInfusion = kin/CLr
This formula uses 3 Variables
Variables Used
Plasma Concentration in Constant Rate Infusion - (Measured in Mole per Cubic Meter) - Plasma Concentration in Constant Rate Infusion is the concentration of the drug after administration and before the next dose is administered.
Rate of Infusion - (Measured in Mole per Second) - The Rate of Infusion is defined as the rate required to balance elimination.
Renal Clearance - (Measured in Cubic Meter per Second) - Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time.
STEP 1: Convert Input(s) to Base Unit
Rate of Infusion: 55 Mole per Second --> 55 Mole per Second No Conversion Required
Renal Clearance: 15.6 Milliliter per Minute --> 2.6E-07 Cubic Meter per Second (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
CInfusion = kin/CLr --> 55/2.6E-07
Evaluating ... ...
CInfusion = 211538461.538462
STEP 3: Convert Result to Output's Unit
211538461.538462 Mole per Cubic Meter -->211538.461538462 Mole per Liter (Check conversion here)
FINAL ANSWER
211538.461538462 211538.5 Mole per Liter <-- Plasma Concentration in Constant Rate Infusion
(Calculation completed in 00.004 seconds)

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National University of Judicial Science (NUJS), Kolkata
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11 Plasma Calculators

Fractional Excretion of Sodium
Go Fractional Excretion of Sodium = (Urine Sodium Concentration*Creatinine Concentration in Plasma)/(Sodium Concentration in Plasma*Creatinine Concentration in Urine)*100
Apparent Tissue Volume given Plasma Volume and Apparent Volume
Go Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)
Plasma Volume of Drug given Apparent Volume
Go Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
Renal Clearance using Rate of Reabsorption
Go Renal Clearance = Filtration Rate+(Secretion Rate of Drug-Reabsorption Rate of Drug)/Plasma Concentration
Average Plasma Concentration given Peak through Fluctuation
Go Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation
Lowest Plasma Concentration Given Peak through Fluctuation
Go Lowest Plasma Concentration = Peak Plasma Concentration-(Average Plasma Concentration*Peak Through Fluctuation)
Peak Plasma Concentration Given Peak through Fluctuation
Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration
Peak through Fluctuation
Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration
Average Concentration of Plasma at Steady State
Go Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
Plasma Concentration of Constant Rate Infusion at Steady State
Go Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance
Initial Concentration for Intravenous Bolus
Go Initial Plasma Concentration = Dose/Volume of Distribution

Plasma Concentration of Constant Rate Infusion at Steady State Formula

Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance
CInfusion = kin/CLr

What is Pharmacokinetics ?

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.

How to Calculate Plasma Concentration of Constant Rate Infusion at Steady State?

Plasma Concentration of Constant Rate Infusion at Steady State calculator uses Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance to calculate the Plasma Concentration in Constant Rate Infusion, The Plasma Concentration of Constant Rate Infusion at Steady State formula is defined as the amount of plasma concentration which is calculated using clearance and rate of infusion. Plasma Concentration in Constant Rate Infusion is denoted by CInfusion symbol.

How to calculate Plasma Concentration of Constant Rate Infusion at Steady State using this online calculator? To use this online calculator for Plasma Concentration of Constant Rate Infusion at Steady State, enter Rate of Infusion (kin) & Renal Clearance (CLr) and hit the calculate button. Here is how the Plasma Concentration of Constant Rate Infusion at Steady State calculation can be explained with given input values -> 211.5385 = 55/2.6E-07.

FAQ

What is Plasma Concentration of Constant Rate Infusion at Steady State?
The Plasma Concentration of Constant Rate Infusion at Steady State formula is defined as the amount of plasma concentration which is calculated using clearance and rate of infusion and is represented as CInfusion = kin/CLr or Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance. The Rate of Infusion is defined as the rate required to balance elimination & Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time.
How to calculate Plasma Concentration of Constant Rate Infusion at Steady State?
The Plasma Concentration of Constant Rate Infusion at Steady State formula is defined as the amount of plasma concentration which is calculated using clearance and rate of infusion is calculated using Plasma Concentration in Constant Rate Infusion = Rate of Infusion/Renal Clearance. To calculate Plasma Concentration of Constant Rate Infusion at Steady State, you need Rate of Infusion (kin) & Renal Clearance (CLr). With our tool, you need to enter the respective value for Rate of Infusion & Renal Clearance and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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