Previous Rate of Drug Dose given Revised Dose Calculator

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Dose

Area under curve

Bioavailability

Drug Content

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Revised dose calculated based on concentration of the drug in the patient's bloodstream and the concentration of the drug that was actually measured in the patient's bloodstream (measured CPSS).ⓘ Revised Dose [RD]			+10% -10%
✖The Measured Steady State Concentration Plasma is the actual concentration of the drug that is measured in the patient's bloodstream through therapeutic drug monitoring.ⓘ Measured Steady State Concentration Plasma [M_cpss]			+10% -10%
✖The Target Steady State Plasma Concentration represents the therapeutic range or the optimal concentration that is expected to provide the desired therapeutic effect.ⓘ Target Steady State Plasma Concentration [T_cpss]			+10% -10%

✖Previous Rate of Dose Rate is the dose of the medication that the patient was previously receiving.ⓘ Previous Rate of Drug Dose given Revised Dose [PDR]

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Formula

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Previous Rate of Drug Dose given Revised Dose

Formula

`"PDR" = ("RD"*"M"_{"cpss"})/("T"_{"cpss"})`

Example

`"0.0001kg"=("200mg"*"5mg/L")/("10mg/L")`

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Previous Rate of Drug Dose given Revised Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)
PDR = (RD*M_cpss)/(T_cpss)
This formula uses 4 Variables

Variables Used

Previous Rate of Dose - (Measured in Kilogram) - Previous Rate of Dose Rate is the dose of the medication that the patient was previously receiving.
Revised Dose - (Measured in Kilogram) - The Revised dose calculated based on concentration of the drug in the patient's bloodstream and the concentration of the drug that was actually measured in the patient's bloodstream (measured CPSS).
Measured Steady State Concentration Plasma - (Measured in Kilogram per Cubic Meter) - The Measured Steady State Concentration Plasma is the actual concentration of the drug that is measured in the patient's bloodstream through therapeutic drug monitoring.
Target Steady State Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Steady State Plasma Concentration represents the therapeutic range or the optimal concentration that is expected to provide the desired therapeutic effect.

STEP 1: Convert Input(s) to Base Unit

Revised Dose: 200 Milligram --> 0.0002 Kilogram (Check conversion here)
Measured Steady State Concentration Plasma: 5 Milligram per Liter --> 0.005 Kilogram per Cubic Meter (Check conversion here)
Target Steady State Plasma Concentration: 10 Milligram per Liter --> 0.01 Kilogram per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

PDR = (RD*M_cpss)/(T_cpss) --> (0.0002*0.005)/(0.01)

Evaluating ... ...

PDR = 0.0001

STEP 3: Convert Result to Output's Unit

0.0001 Kilogram --> No Conversion Required

FINAL ANSWER

0.0001 Kilogram <-- Previous Rate of Dose

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Previous Rate of Drug Dose given Revised Dose Formula

Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)
PDR = (RD*M_cpss)/(T_cpss)

What are the characteristics of the drug suitable for therapeutic drug monitoring ?

The drug must have the following properties:

a. Narrow therapeutic index
b. Marked inter-individual pharmacokinetic variability
c. The desired therapeutic effect is difficult to monitor
d. Direct correlation between plasma concentration of drug/metabolite and pharmacological effect
e. Availability of appropriate analytical test/technique to determine drug or its metabolite level.

How to Calculate Previous Rate of Drug Dose given Revised Dose?

Previous Rate of Drug Dose given Revised Dose calculator uses Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration) to calculate the Previous Rate of Dose, The Previous Rate of Drug Dose given Revised Dose formula is defined as the ratio of the product of the revised dose and measured steady state plasma concentration to the target steady state plasma concentration. Previous Rate of Dose is denoted by PDR symbol.

How to calculate Previous Rate of Drug Dose given Revised Dose using this online calculator? To use this online calculator for Previous Rate of Drug Dose given Revised Dose, enter Revised Dose (RD), Measured Steady State Concentration Plasma (M_cpss) & Target Steady State Plasma Concentration (T_cpss) and hit the calculate button. Here is how the Previous Rate of Drug Dose given Revised Dose calculation can be explained with given input values -> 0.0001 = (0.0002*0.005)/(0.01).

FAQ

What is Previous Rate of Drug Dose given Revised Dose?

The Previous Rate of Drug Dose given Revised Dose formula is defined as the ratio of the product of the revised dose and measured steady state plasma concentration to the target steady state plasma concentration and is represented as PDR = (RD*M_cpss)/(T_cpss) or Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration). The Revised dose calculated based on concentration of the drug in the patient's bloodstream and the concentration of the drug that was actually measured in the patient's bloodstream (measured CPSS), The Measured Steady State Concentration Plasma is the actual concentration of the drug that is measured in the patient's bloodstream through therapeutic drug monitoring & The Target Steady State Plasma Concentration represents the therapeutic range or the optimal concentration that is expected to provide the desired therapeutic effect.

How to calculate Previous Rate of Drug Dose given Revised Dose?

The Previous Rate of Drug Dose given Revised Dose formula is defined as the ratio of the product of the revised dose and measured steady state plasma concentration to the target steady state plasma concentration is calculated using Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration). To calculate Previous Rate of Drug Dose given Revised Dose, you need Revised Dose (RD), Measured Steady State Concentration Plasma (M_cpss) & Target Steady State Plasma Concentration (T_cpss). With our tool, you need to enter the respective value for Revised Dose, Measured Steady State Concentration Plasma & Target Steady State Plasma Concentration and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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