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Renal Clearance of Drug Solution

STEP 0: Pre-Calculation Summary
Formula Used
Renal_Clearance = Drug Amount Excreted Unchanged in Urine/Area under Curve
CLr = Au/AUC
This formula uses 2 Variables
Variables Used
Drug Amount Excreted Unchanged in Urine - Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine. (Measured in Microgram per Liter)
Area under Curve - The Area under Curve is an integral of the concentration-time curve (after a single dose or in steady-state). (Measured in Mole Second per Liter)
STEP 1: Convert Input(s) to Base Unit
Drug Amount Excreted Unchanged in Urine: 10 Microgram per Liter --> 1E-05 Kilogram per Meter³ (Check conversion here)
Area under Curve: 1.32 Mole Second per Liter --> 1320 Mole Second per Cubic Meter (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
CLr = Au/AUC --> 1E-05/1320
Evaluating ... ...
CLr = 7.57575757575758E-09
STEP 3: Convert Result to Output's Unit
7.57575757575758E-09 Meter³ per Second -->0.454545454545455 Milliliter per Min (Check conversion here)
FINAL ANSWER
0.454545454545455 Milliliter per Min <-- Renal Clearance
(Calculation completed in 00.000 seconds)

10+ Organic Chemistry>> Pharmacokinetics Calculators

Elimination half life given volume of plasma cleared
elimination_half_life = (ln(2)*Volume of Distribution)/Volume of plasma cleared Go
Elimination rate constant given area under curve
elimination_rate_constant = Dose/(Area under Curve*Volume of Distribution) Go
Elimination rate constant given volume of plasma cleared
elimination_rate_constant = Volume of plasma cleared/Volume of Distribution Go
Concentration of drug given rate of infusion of drug
concentration_of_drug = Rate of infusion/Volume of plasma cleared Go
Rate of infusion of drug
rate_of_infusion = Volume of plasma cleared*Concentration of drug Go
Elimination rate constant of drug
elimination_rate_constant = ln(2)/Elimination half life Go
Elimination half life of drug
elimination_half_life = ln(2)/Elimination rate constant Go
Rate at which drug enters into body
absorption_rate_constant = ln(2)/Absorption half life Go
Absorption half life of drug
absorption_half_life = ln(2)/Absorption rate constant Go
Apparent volume of drug distribution
volume_of_distribution = Dose/Concentration of drug Go

Renal Clearance of Drug Formula

Renal_Clearance = Drug Amount Excreted Unchanged in Urine/Area under Curve
CLr = Au/AUC

What is Pharmacokinetics ?

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.

How to Calculate Renal Clearance of Drug?

Renal Clearance of Drug calculator uses Renal_Clearance = Drug Amount Excreted Unchanged in Urine/Area under Curve to calculate the Renal Clearance, The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute. Renal Clearance is denoted by CLr symbol.

How to calculate Renal Clearance of Drug using this online calculator? To use this online calculator for Renal Clearance of Drug, enter Drug Amount Excreted Unchanged in Urine (Au) & Area under Curve (AUC) and hit the calculate button. Here is how the Renal Clearance of Drug calculation can be explained with given input values -> 0.454545 = 1E-05/1320.

FAQ

What is Renal Clearance of Drug?
The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute and is represented as CLr = Au/AUC or Renal_Clearance = Drug Amount Excreted Unchanged in Urine/Area under Curve. Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine & The Area under Curve is an integral of the concentration-time curve (after a single dose or in steady-state).
How to calculate Renal Clearance of Drug?
The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute is calculated using Renal_Clearance = Drug Amount Excreted Unchanged in Urine/Area under Curve. To calculate Renal Clearance of Drug, you need Drug Amount Excreted Unchanged in Urine (Au) & Area under Curve (AUC). With our tool, you need to enter the respective value for Drug Amount Excreted Unchanged in Urine & Area under Curve and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
How many ways are there to calculate Renal Clearance?
In this formula, Renal Clearance uses Drug Amount Excreted Unchanged in Urine & Area under Curve. We can use 10 other way(s) to calculate the same, which is/are as follows -
  • volume_of_distribution = Dose/Concentration of drug
  • absorption_half_life = ln(2)/Absorption rate constant
  • absorption_rate_constant = ln(2)/Absorption half life
  • elimination_half_life = ln(2)/Elimination rate constant
  • elimination_rate_constant = ln(2)/Elimination half life
  • elimination_rate_constant = Volume of plasma cleared/Volume of Distribution
  • elimination_half_life = (ln(2)*Volume of Distribution)/Volume of plasma cleared
  • rate_of_infusion = Volume of plasma cleared*Concentration of drug
  • concentration_of_drug = Rate of infusion/Volume of plasma cleared
  • elimination_rate_constant = Dose/(Area under Curve*Volume of Distribution)
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