Target Plasma Concentration given Loading Dose Calculator

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Dose

Area under curve

Bioavailability

Drug Content

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration.ⓘ Loading Dose [LD]			+10% -10%
✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability Of drug dose [F%]			+10% -10%
✖The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma.ⓘ Volume Of Distribution dose [V_d]			+10% -10%

✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration given Loading Dose [C_p]

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Formula

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Target Plasma Concentration given Loading Dose

Formula

`"C"_{"p"} = ("LD"*"F%")/"V"_{"d"}`

Example

`"0.9mg/L"=("50mg"*"0.9")/"50L"`

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Target Plasma Concentration given Loading Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Target Plasma Concentration = (Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose
C_p = (LD*F%)/V_d
This formula uses 4 Variables

Variables Used

Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Loading Dose - (Measured in Kilogram) - The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration.
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.
Volume Of Distribution dose - (Measured in Cubic Meter) - The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma.

STEP 1: Convert Input(s) to Base Unit

Loading Dose: 50 Milligram --> 5E-05 Kilogram (Check conversion here)
Bioavailability Of drug dose: 0.9 --> No Conversion Required
Volume Of Distribution dose: 50 Liter --> 0.05 Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

C_p = (LD*F%)/V_d --> (5E-05*0.9)/0.05

Evaluating ... ...

C_p = 0.0009

STEP 3: Convert Result to Output's Unit

0.0009 Kilogram per Cubic Meter -->0.9 Milligram per Liter (Check conversion here)

FINAL ANSWER

0.9 Milligram per Liter <-- Target Plasma Concentration

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Target Plasma Concentration given Loading Dose Formula

Target Plasma Concentration = (Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose
C_p = (LD*F%)/V_d

What is the purpose of loading dose ?

A loading dose is used to quickly achieve a high plasma concentration of drug.
Without a loading dose, it can take quite a bit of time to reach steady state: 4-5 half-lives, which (as in the case of refractory seizures) may be too long. Loading dose is a measurement of distribution x concentration.
It dose is the dose of a drug we use to achieve a high plasma concentration (targeting steady state concentration), quickly; we show a syringe because it is often given intravenously.

How to Calculate Target Plasma Concentration given Loading Dose?

Target Plasma Concentration given Loading Dose calculator uses Target Plasma Concentration = (Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose to calculate the Target Plasma Concentration, The Target Plasma Concentration given Loading Dose formula is defined as the ratio of the product of the loading dose and bioavailability of drug dose to the volume of dose distribution. Target Plasma Concentration is denoted by C_p symbol.

How to calculate Target Plasma Concentration given Loading Dose using this online calculator? To use this online calculator for Target Plasma Concentration given Loading Dose, enter Loading Dose (LD), Bioavailability Of drug dose (F%) & Volume Of Distribution dose (V_d) and hit the calculate button. Here is how the Target Plasma Concentration given Loading Dose calculation can be explained with given input values -> 2.7E+10 = (5E-05*0.9)/0.05.

FAQ

What is Target Plasma Concentration given Loading Dose?

The Target Plasma Concentration given Loading Dose formula is defined as the ratio of the product of the loading dose and bioavailability of drug dose to the volume of dose distribution and is represented as C_p = (LD*F%)/V_d or Target Plasma Concentration = (Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose. The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration, The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form & The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma.

How to calculate Target Plasma Concentration given Loading Dose?

The Target Plasma Concentration given Loading Dose formula is defined as the ratio of the product of the loading dose and bioavailability of drug dose to the volume of dose distribution is calculated using Target Plasma Concentration = (Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose. To calculate Target Plasma Concentration given Loading Dose, you need Loading Dose (LD), Bioavailability Of drug dose (F%) & Volume Of Distribution dose (V_d). With our tool, you need to enter the respective value for Loading Dose, Bioavailability Of drug dose & Volume Of Distribution dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Target Plasma Concentration?

In this formula, Target Plasma Concentration uses Loading Dose, Bioavailability Of drug dose & Volume Of Distribution dose. We can use 2 other way(s) to calculate the same, which is/are as follows -

Target Plasma Concentration = (Revised Dose*Measured Steady State Concentration Plasma)/Previous Rate of Dose
Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance)

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