Target Plasma Concentration given Maintenance Dose Calculator

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✖The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.ⓘ Maintenance Dose [MD]			+10% -10%
✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability Of drug dose [F%]			+10% -10%
✖Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Drug Clearance [CL_drug]			+10% -10%

✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration given Maintenance Dose [C_p]

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Formula

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Target Plasma Concentration given Maintenance Dose

Formula

`"C"_{"p"} = ("MD"*"F%"/"CL"_{"drug"})`

Example

`"8.7E^-6mg/L"=("70mg/h"*"0.9"/"2m³/s")`

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Target Plasma Concentration given Maintenance Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance)
C_p = (MD*F%/CL_drug)
This formula uses 4 Variables

Variables Used

Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.
Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

STEP 1: Convert Input(s) to Base Unit

Maintenance Dose: 70 Milligram per Hour --> 1.94444444444444E-08 Kilogram per Second (Check conversion here)
Bioavailability Of drug dose: 0.9 --> No Conversion Required
Drug Clearance: 2 Cubic Meter per Second --> 2 Cubic Meter per Second No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

C_p = (MD*F%/CL_drug) --> (1.94444444444444E-08*0.9/2)

Evaluating ... ...

C_p = 8.74999999999998E-09

STEP 3: Convert Result to Output's Unit

8.74999999999998E-09 Kilogram per Cubic Meter -->8.74999999999998E-06 Milligram per Liter (Check conversion here)

FINAL ANSWER

8.74999999999998E-06 ≈ 8.7E-6 Milligram per Liter <-- Target Plasma Concentration

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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< 25 Dose Calculators

Dose of drug administered orally

Go Dose Non-Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Bioavailability of Drug)

Dose of drug administered intravenous

Go Dose Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Area under Curve Non-Intravenous

Dose of A type drug

Go Dose Type A = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Relative Bioavailability)

Dose of B type drug

Go Dose Type B = (Relative Bioavailability*Dose Type A)*(Area under curve Dosage B/Area under curve Dosage A)

Administrative dose given rate of administration and dosing interval

Go Administered Dose = (Drug Rate of Administration*Dosing Interval)/(Bioavailability*Drug Purity)

Previous Rate of Drug Dose given Revised Dose

Go Previous Rate of Dose = (Revised Dose*Measured Steady State Concentration Plasma)/(Target Steady State Plasma Concentration)

Dosing interval given rate of administration

Go Dosing Interval = (Administered Dose*Bioavailability*Drug Purity)/Drug Rate of Administration

Revised Dose

Go Revised Dose = Previous Rate of Dose*Target Steady State Plasma Concentration/Measured Steady State Concentration Plasma

Loading Dose

Go Loading Dose = (Target Plasma Concentration*Volume Of Distribution dose)/Bioavailability Of drug dose

Maintenance Dose

Go Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose

Dose given volume of distribution and area under curve

Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Administrative Dose given Drug Purity

Go Administered Dose = Effective Dose/(Drug Purity*Bioavailability)

Effective dose given drug purity

Go Effective Dose = Drug Purity*Bioavailability*Administered Dose

Adult Dose of Drug by Clark's Equation in Micrograms

Go Adult Dose = Pediatric Dosage/(Weight of Patient in microgram/68)

Clark's Equation of Dosage in Microgram

Go Pediatric Dosage = Adult Dose*(Weight of Patient in microgram/68)

Dosing interval given average plasma concentration

Go Dosing Interval = Area Under Curve/Average Plasma Concentration

Adult Dose of Drug by Clark's Equation

Go Adult Dose = Pediatric Dosage/(Weight of Patient/150)

Weight of Patient by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*150

Clark's Equation of Dosage

Go Pediatric Dosage = Adult Dose*(Weight of Patient/150)

Weight of Patient in Kilograms by Clark's equation

Go Weight of Patient = (Pediatric Dosage/Adult Dose)*68

Amount of drug administered given apparent volume

Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

Go Concentration of Drug = Dose/Volume of Distribution

Administrative dose given effective dose and bioavailability

Go Administered Dose = Effective Dose/Bioavailability

Effective dose given bioavailability and administrative dose

Go Effective Dose = Bioavailability*Administered Dose

Amount of drug administered given area under curve

Go Dose = Volume of Plasma Cleared*Area Under Curve

Target Plasma Concentration given Maintenance Dose Formula

Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance)
C_p = (MD*F%/CL_drug)

How does loading dose useful for drugs ?

A loading dose is most useful for drugs that are eliminated from the body relatively slowly. Such drugs need only a low maintenance dose in order to keep the amount of the drug in the body at the appropriate level, but this also means that, without an initial higher dose, it would take a long time for the amount of the drug in the body to reach that level.

How to Calculate Target Plasma Concentration given Maintenance Dose?

Target Plasma Concentration given Maintenance Dose calculator uses Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance) to calculate the Target Plasma Concentration, The Target Plasma Concentration given Maintenance Dose formula is defined as the ratio of the product of the maintenance dose and bioavailaility of drug to the clearance of drug. Target Plasma Concentration is denoted by C_p symbol.

How to calculate Target Plasma Concentration given Maintenance Dose using this online calculator? To use this online calculator for Target Plasma Concentration given Maintenance Dose, enter Maintenance Dose (MD), Bioavailability Of drug dose (F%) & Drug Clearance (CL_drug) and hit the calculate button. Here is how the Target Plasma Concentration given Maintenance Dose calculation can be explained with given input values -> 0.00875 = (1.94444444444444E-08*0.9/2).

FAQ

What is Target Plasma Concentration given Maintenance Dose?

The Target Plasma Concentration given Maintenance Dose formula is defined as the ratio of the product of the maintenance dose and bioavailaility of drug to the clearance of drug and is represented as C_p = (MD*F%/CL_drug) or Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance). The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration, The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form & Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

How to calculate Target Plasma Concentration given Maintenance Dose?

The Target Plasma Concentration given Maintenance Dose formula is defined as the ratio of the product of the maintenance dose and bioavailaility of drug to the clearance of drug is calculated using Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance). To calculate Target Plasma Concentration given Maintenance Dose, you need Maintenance Dose (MD), Bioavailability Of drug dose (F%) & Drug Clearance (CL_drug). With our tool, you need to enter the respective value for Maintenance Dose, Bioavailability Of drug dose & Drug Clearance and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Target Plasma Concentration?

In this formula, Target Plasma Concentration uses Maintenance Dose, Bioavailability Of drug dose & Drug Clearance. We can use 2 other way(s) to calculate the same, which is/are as follows -

Target Plasma Concentration = (Revised Dose*Measured Steady State Concentration Plasma)/Previous Rate of Dose
Target Plasma Concentration = (Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose

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