## Therapeutic Index Solution

STEP 0: Pre-Calculation Summary
Formula Used
Therapeutic Index = Median Lethal Dose/Median Effective Dose
TI = LD50/ED50
This formula uses 3 Variables
Variables Used
Therapeutic Index - The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.
Median Lethal Dose - (Measured in Kilogram) - The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.
Median Effective Dose - (Measured in Kilogram) - The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.
STEP 1: Convert Input(s) to Base Unit
Median Lethal Dose: 150 Milligram --> 0.00015 Kilogram (Check conversion here)
Median Effective Dose: 20 Milligram --> 2E-05 Kilogram (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
TI = LD50/ED50 --> 0.00015/2E-05
Evaluating ... ...
TI = 7.5
STEP 3: Convert Result to Output's Unit
7.5 --> No Conversion Required
7.5 <-- Therapeutic Index
(Calculation completed in 00.020 seconds)
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## Credits

Created by Ritacheta Sen
University of Calcutta (C.U), Kolkata
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National University of Judicial Science (NUJS), Kolkata
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## < 21 Drug Content Calculators

Saponification value
Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken
Fraction of Drug Unbound in Tissue given Apparent Tissue Volume
Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)
Secretion Rate of Drug
Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)
Reabsorption Rate of Drug
Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)
Filtration Rate of Drug
Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)
Relative Bioavailability of Drug
Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)
Acid Value of KOH
Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken
Drug Purity given Rate of Administration and Dosing Interval
Rate of Administration of Drug given Dosing Interval
Drug Purity given Administrative Dose and Effective Dose
Drug Purity = Effective Dose/(Administered Dose*Bioavailability)
Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100
Encapsulation Efficiency
Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100
Renal Clearance of Drug
Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve
Concentration of Drug given Rate of Infusion of Drug
Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared
Rate of Infusion of Drug
Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug
Therapeutic Index
Therapeutic Index = Median Lethal Dose/Median Effective Dose
Absorption Half-Life of Drug
Absorption Half Life = ln(2)/Absorption Rate Constant
Drug Rate Entering Body
Absorption Rate Constant = ln(2)/Absorption Half Life
Apparent Volume of Drug Distribution
Volume of Distribution = Dose/Concentration of Drug
Tablet Dosage
Number of tablet = Desired dosage/Stock strength
Easter Value
Easter Value = Saponification Value-Acid Value

## Therapeutic Index Formula

Therapeutic Index = Median Lethal Dose/Median Effective Dose
TI = LD50/ED50

## What is the range of LD50 and ED50?

The Therapeutic Index formula is defined as a measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose. The therapeutic index provides information about the separation between the dose that produces the desired therapeutic effect and the dose that produces toxic effects.
LD50 is the Median Lethal Dose, which represents the dose at which 50% of the population exhibits toxic effects or dies.
ED50 is the Median Effective Dose, which represents the dose at which 50% of the population exhibits the desired therapeutic effect.

## How to Calculate Therapeutic Index?

Therapeutic Index calculator uses Therapeutic Index = Median Lethal Dose/Median Effective Dose to calculate the Therapeutic Index, Therapeutic Index is defined as the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response. Therapeutic Index is denoted by TI symbol.

How to calculate Therapeutic Index using this online calculator? To use this online calculator for Therapeutic Index, enter Median Lethal Dose (LD50) & Median Effective Dose (ED50) and hit the calculate button. Here is how the Therapeutic Index calculation can be explained with given input values -> 7.5 = 0.00015/2E-05.

### FAQ

What is Therapeutic Index?
Therapeutic Index is defined as the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response and is represented as TI = LD50/ED50 or Therapeutic Index = Median Lethal Dose/Median Effective Dose. The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies & The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.
How to calculate Therapeutic Index?
Therapeutic Index is defined as the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response is calculated using Therapeutic Index = Median Lethal Dose/Median Effective Dose. To calculate Therapeutic Index, you need Median Lethal Dose (LD50) & Median Effective Dose (ED50). With our tool, you need to enter the respective value for Median Lethal Dose & Median Effective Dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well. Let Others Know