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Therapeutic Index Calculator

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✖The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.ⓘ Median Lethal Dose [LD50]			+10% -10%
✖The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.ⓘ Median Effective Dose [ED50]			+10% -10%

✖The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.ⓘ Therapeutic Index [TI]

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Therapeutic Index Solution

STEP 0: Pre-Calculation Summary

Formula Used

Therapeutic Index = Median Lethal Dose/Median Effective Dose
TI = LD50/ED50
This formula uses 3 Variables

Variables Used

Therapeutic Index - The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.
Median Lethal Dose - (Measured in Kilogram) - The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.
Median Effective Dose - (Measured in Kilogram) - The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.

STEP 1: Convert Input(s) to Base Unit

Median Lethal Dose: 150 Milligram --> 0.00015 Kilogram (Check conversion here)
Median Effective Dose: 20 Milligram --> 2E-05 Kilogram (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

TI = LD50/ED50 --> 0.00015/2E-05

Evaluating ... ...

TI = 7.5

STEP 3: Convert Result to Output's Unit

7.5 --> No Conversion Required

FINAL ANSWER

7.5 <-- Therapeutic Index

(Calculation completed in 00.006 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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Therapeutic Index Formula

LaTeX Go

Therapeutic Index = Median Lethal Dose/Median Effective Dose
TI = LD50/ED50

What is the range of LD50 and ED50?

The Therapeutic Index formula is defined as a measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose. The therapeutic index provides information about the separation between the dose that produces the desired therapeutic effect and the dose that produces toxic effects.
LD50 is the Median Lethal Dose, which represents the dose at which 50% of the population exhibits toxic effects or dies.
ED50 is the Median Effective Dose, which represents the dose at which 50% of the population exhibits the desired therapeutic effect.

How to Calculate Therapeutic Index?

Therapeutic Index calculator uses Therapeutic Index = Median Lethal Dose/Median Effective Dose to calculate the Therapeutic Index, Therapeutic Index is defined as the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response. Therapeutic Index is denoted by TI symbol.

How to calculate Therapeutic Index using this online calculator? To use this online calculator for Therapeutic Index, enter Median Lethal Dose (LD50) & Median Effective Dose (ED50) and hit the calculate button. Here is how the Therapeutic Index calculation can be explained with given input values -> 7.5 = 0.00015/2E-05.

FAQ

What is Therapeutic Index?

Therapeutic Index is defined as the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response and is represented as TI = LD50/ED50 or Therapeutic Index = Median Lethal Dose/Median Effective Dose. The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies & The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.

How to calculate Therapeutic Index?

Therapeutic Index is defined as the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response is calculated using Therapeutic Index = Median Lethal Dose/Median Effective Dose. To calculate Therapeutic Index, you need Median Lethal Dose (LD50) & Median Effective Dose (ED50). With our tool, you need to enter the respective value for Median Lethal Dose & Median Effective Dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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