Volume of Plasma Cleared given Area under Curve Solution

STEP 0: Pre-Calculation Summary
Formula Used
Volume of Plasma Cleared = Dose/Area Under Curve
CL = D/AUC
This formula uses 3 Variables
Variables Used
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.
Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Area Under Curve - (Measured in Mole Second per Cubic Meter) - Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.
STEP 1: Convert Input(s) to Base Unit
Dose: 8 Mole --> 8 Mole No Conversion Required
Area Under Curve: 1.32 Mole Second per Liter --> 1320 Mole Second per Cubic Meter (Check conversion here)
STEP 2: Evaluate Formula
Substituting Input Values in Formula
CL = D/AUC --> 8/1320
Evaluating ... ...
CL = 0.00606060606060606
STEP 3: Convert Result to Output's Unit
0.00606060606060606 Cubic Meter per Second -->6.06060606060606 Liter per Second (Check conversion here)
FINAL ANSWER
6.06060606060606 Liter per Second <-- Volume of Plasma Cleared
(Calculation completed in 00.014 seconds)

Credits

Created by Prashant Singh
K J Somaiya College of science (K J Somaiya), Mumbai
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5 Volume of plasma cleared Calculators

Fraction of Drug Unbound in Plasma given Plasma Volume
Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue Go
Volume of Plasma Cleared given Elimination Half Life
Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life Go
Volume of Plasma Cleared of Drug given Rate at which Drug is Removed
Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution Go
Volume of Plasma Cleared given Rate of Infusion
Volume of Plasma Cleared = Rate of Infusion/Concentration of Drug Go
Volume of Plasma Cleared given Area under Curve
Volume of Plasma Cleared = Dose/Area Under Curve Go

Volume of Plasma Cleared given Area under Curve Formula

Volume of Plasma Cleared = Dose/Area Under Curve
CL = D/AUC

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Volume of Plasma Cleared given Area under Curve?

Volume of Plasma Cleared given Area under Curve calculator uses Volume of Plasma Cleared = Dose/Area Under Curve to calculate the Volume of Plasma Cleared, The Volume of Plasma Cleared given Area under Curve formula is defined as the ratio of the amount of drug administered to the area under the curve. Volume of Plasma Cleared is denoted by CL symbol.

How to calculate Volume of Plasma Cleared given Area under Curve using this online calculator? To use this online calculator for Volume of Plasma Cleared given Area under Curve, enter Dose (D) & Area Under Curve (AUC) and hit the calculate button. Here is how the Volume of Plasma Cleared given Area under Curve calculation can be explained with given input values -> 6.060606 = 8/1320.

FAQ

What is Volume of Plasma Cleared given Area under Curve?
The Volume of Plasma Cleared given Area under Curve formula is defined as the ratio of the amount of drug administered to the area under the curve and is represented as CL = D/AUC or Volume of Plasma Cleared = Dose/Area Under Curve. The Dose is the amount of drug administered & Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.
How to calculate Volume of Plasma Cleared given Area under Curve?
The Volume of Plasma Cleared given Area under Curve formula is defined as the ratio of the amount of drug administered to the area under the curve is calculated using Volume of Plasma Cleared = Dose/Area Under Curve. To calculate Volume of Plasma Cleared given Area under Curve, you need Dose (D) & Area Under Curve (AUC). With our tool, you need to enter the respective value for Dose & Area Under Curve and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
How many ways are there to calculate Volume of Plasma Cleared?
In this formula, Volume of Plasma Cleared uses Dose & Area Under Curve. We can use 3 other way(s) to calculate the same, which is/are as follows -
  • Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution
  • Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life
  • Volume of Plasma Cleared = Rate of Infusion/Concentration of Drug
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