Volume of Plasma Cleared of Drug given Rate at which Drug is Removed Calculator

↳

⤿

Volume of plasma cleared

Area under curve

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

✖Elimination Rate Constant is the rate at which a drug is removed from the body.ⓘ Elimination Rate Constant [k_e]			+10% -10%
✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%

✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared of Drug given Rate at which Drug is Removed [CL]

⎘ Copy

👎

Formula

✖

Volume of Plasma Cleared of Drug given Rate at which Drug is Removed

Formula

`"CL" = "k"_{"e"}*"V"_{"d"}`

Example

`"0.000145L/s"="0.058h⁻¹"*"9L"`

Calculator

LaTeX

Reset

👍

Download Pharmacokinetics Formula PDF

Volume of Plasma Cleared of Drug given Rate at which Drug is Removed Solution

STEP 0: Pre-Calculation Summary

Formula Used

Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution
CL = k_e*V_d
This formula uses 3 Variables

Variables Used

Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.
Elimination Rate Constant - (Measured in 1 Per Second) - Elimination Rate Constant is the rate at which a drug is removed from the body.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

STEP 1: Convert Input(s) to Base Unit

Elimination Rate Constant: 0.058 1 Per Hour --> 1.61111111111111E-05 1 Per Second (Check conversion here)
Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

CL = k_e*V_d --> 1.61111111111111E-05*0.009

Evaluating ... ...

CL = 1.45E-07

STEP 3: Convert Result to Output's Unit

1.45E-07 Cubic Meter per Second -->0.000145 Liter per Second (Check conversion here)

FINAL ANSWER

0.000145 Liter per Second <-- Volume of Plasma Cleared

(Calculation completed in 00.020 seconds)

You are here -

Home » Chemistry » Pharmacokinetics » Volume of plasma cleared » Volume of Plasma Cleared of Drug given Rate at which Drug is Removed

Credits

Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

Prashant Singh has created this Calculator and 700+ more calculators!

Verified by Prerana Bakli

University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA

Prerana Bakli has verified this Calculator and 1600+ more calculators!

< 5 Volume of plasma cleared Calculators

Fraction of Drug Unbound in Plasma given Plasma Volume

Go Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue

Volume of Plasma Cleared given Elimination Half Life

Go Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life

Volume of Plasma Cleared of Drug given Rate at which Drug is Removed

Go Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution

Volume of Plasma Cleared given Rate of Infusion

Go Volume of Plasma Cleared = Rate of Infusion/Concentration of Drug

Volume of Plasma Cleared given Area under Curve

Go Volume of Plasma Cleared = Dose/Area Under Curve

Volume of Plasma Cleared of Drug given Rate at which Drug is Removed Formula

Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution
CL = k_e*V_d

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Volume of Plasma Cleared of Drug given Rate at which Drug is Removed?

Volume of Plasma Cleared of Drug given Rate at which Drug is Removed calculator uses Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution to calculate the Volume of Plasma Cleared, The Volume of plasma cleared of drug given rate at which drug is removed formula is defined as the product of the rate at which a drug is removed from the body to the apparent volume in which a drug is distributed. Volume of Plasma Cleared is denoted by CL symbol.

How to calculate Volume of Plasma Cleared of Drug given Rate at which Drug is Removed using this online calculator? To use this online calculator for Volume of Plasma Cleared of Drug given Rate at which Drug is Removed, enter Elimination Rate Constant (k_e) & Volume of Distribution (V_d) and hit the calculate button. Here is how the Volume of Plasma Cleared of Drug given Rate at which Drug is Removed calculation can be explained with given input values -> 0.145 = 1.61111111111111E-05*0.009.

FAQ

What is Volume of Plasma Cleared of Drug given Rate at which Drug is Removed?

The Volume of plasma cleared of drug given rate at which drug is removed formula is defined as the product of the rate at which a drug is removed from the body to the apparent volume in which a drug is distributed and is represented as CL = k_e*V_d or Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution. Elimination Rate Constant is the rate at which a drug is removed from the body & The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

How to calculate Volume of Plasma Cleared of Drug given Rate at which Drug is Removed?

The Volume of plasma cleared of drug given rate at which drug is removed formula is defined as the product of the rate at which a drug is removed from the body to the apparent volume in which a drug is distributed is calculated using Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution. To calculate Volume of Plasma Cleared of Drug given Rate at which Drug is Removed, you need Elimination Rate Constant (k_e) & Volume of Distribution (V_d). With our tool, you need to enter the respective value for Elimination Rate Constant & Volume of Distribution and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Volume of Plasma Cleared?

In this formula, Volume of Plasma Cleared uses Elimination Rate Constant & Volume of Distribution. We can use 3 other way(s) to calculate the same, which is/are as follows -

Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life
Volume of Plasma Cleared = Rate of Infusion/Concentration of Drug
Volume of Plasma Cleared = Dose/Area Under Curve

Home

FREE PDFs

🔍 Search