What is competitive Inhibition?
In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time, as shown in the figure on the right. This usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate and inhibitor compete for access to the enzyme's active site. This type of inhibition can be overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. However, the apparent Km will increase as it takes a higher concentration of the substrate to reach the Km point, or half the Vmax. Competitive inhibitors are often similar in structure to the real substrate.
How to Calculate Maximum Rate given Rate Constant and Initial Enzyme Concentration?
Maximum Rate given Rate Constant and Initial Enzyme Concentration calculator uses Maximum Rate = (Final Rate Constant*Initial Enzyme Concentration) to calculate the Maximum Rate, The Maximum rate given rate constant and initial enzyme concentration formula is defined as the product of the rate constant of the reaction converting enzyme-substrate intermediate to the product with the initial concentration of enzyme. Maximum Rate is denoted by V_{max} symbol.
How to calculate Maximum Rate given Rate Constant and Initial Enzyme Concentration using this online calculator? To use this online calculator for Maximum Rate given Rate Constant and Initial Enzyme Concentration, enter Final Rate Constant (k_{2}) & Initial Enzyme Concentration ([E_{0}]) and hit the calculate button. Here is how the Maximum Rate given Rate Constant and Initial Enzyme Concentration calculation can be explained with given input values -> 2.3 = (23*100000).