Total Clearance of Body Calculator

⤿

Elimination Rate Constant

Area under curve

Bioavailability

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Hepatic Clearance is the clearance of a drug by the liver. The liver is a major organ for drug metabolism, and it is responsible for breaking down and eliminating many drugs from the body.ⓘ Hepatic Clearance [CL_hepatic]			+10% -10%
✖The Renal Clearance for Total is the clearance of a drug by the kidneys. The kidneys are responsible for filtering out drugs from the blood, and they are a major route of drug elimination.ⓘ Renal Clearance for Total [CL_renal]			+10% -10%
✖The Pulmonary Clearance is the clearance of a drug by the lungs. The lungs are responsible for exchanging gases in the blood, and they can also eliminate some drugs from the body.ⓘ Pulmonary Clearance [CL_pulmonary]			+10% -10%
✖The Other Clearance is the clearance of a drug by other organs or tissues. There are organs and tissues that can contribute to the clearance of drugs, such as the gut, the brain, and the skin.ⓘ Other Clearance [CL_other]			+10% -10%

✖The Total Clearance is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body.ⓘ Total Clearance of Body [CL_total]

⎘ Copy

👎

Formula

✖

Total Clearance of Body

Formula

`"CL"_{"total"} = "CL"_{"hepatic"}+"CL"_{"renal"}+"CL"_{"pulmonary"}+"CL"_{"other"}`

Example

`"5.2L/h"="1.5L/h"+"2L/h"+"1.5L/h"+"0.2L/h"`

Calculator

LaTeX

Reset

👍

Download Pharmacokinetics Formula PDF PDF Image

Total Clearance of Body Solution

STEP 0: Pre-Calculation Summary

Formula Used

Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance
CL_total = CL_hepatic+CL_renal+CL_pulmonary+CL_other
This formula uses 5 Variables

Variables Used

Total Clearance - (Measured in Cubic Meter per Second) - The Total Clearance is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body.
Hepatic Clearance - (Measured in Cubic Meter per Second) - The Hepatic Clearance is the clearance of a drug by the liver. The liver is a major organ for drug metabolism, and it is responsible for breaking down and eliminating many drugs from the body.
Renal Clearance for Total - (Measured in Cubic Meter per Second) - The Renal Clearance for Total is the clearance of a drug by the kidneys. The kidneys are responsible for filtering out drugs from the blood, and they are a major route of drug elimination.
Pulmonary Clearance - (Measured in Cubic Meter per Second) - The Pulmonary Clearance is the clearance of a drug by the lungs. The lungs are responsible for exchanging gases in the blood, and they can also eliminate some drugs from the body.
Other Clearance - (Measured in Cubic Meter per Second) - The Other Clearance is the clearance of a drug by other organs or tissues. There are organs and tissues that can contribute to the clearance of drugs, such as the gut, the brain, and the skin.

STEP 1: Convert Input(s) to Base Unit

Hepatic Clearance: 1.5 Liter per hour --> 4.16666666666667E-07 Cubic Meter per Second (Check conversion here)
Renal Clearance for Total: 2 Liter per hour --> 5.55555555555556E-07 Cubic Meter per Second (Check conversion here)
Pulmonary Clearance: 1.5 Liter per hour --> 4.16666666666667E-07 Cubic Meter per Second (Check conversion here)
Other Clearance: 0.2 Liter per hour --> 5.55555555555556E-08 Cubic Meter per Second (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

CL_total = CL_hepatic+CL_renal+CL_pulmonary+CL_other --> 4.16666666666667E-07+5.55555555555556E-07+4.16666666666667E-07+5.55555555555556E-08

Evaluating ... ...

CL_total = 1.44444444444445E-06

STEP 3: Convert Result to Output's Unit

1.44444444444445E-06 Cubic Meter per Second -->5.2 Liter per hour (Check conversion here)

FINAL ANSWER

5.2 Liter per hour <-- Total Clearance

(Calculation completed in 00.004 seconds)

You are here -

Home » Chemistry » Pharmacokinetics » Elimination Rate Constant » Total Clearance of Body

Credits

Created by swapnalijadhav

idealinstituteofpharmacy (iip), Maharashtra

swapnalijadhav has created this Calculator and 10+ more calculators!

Verified by Prerana Bakli

University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA

Prerana Bakli has verified this Calculator and 1600+ more calculators!

< 6 Elimination Rate Constant Calculators

Total Clearance of Body

Go Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance

Elimination Half Life given Volume of Plasma Cleared

Go Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared

Elimination Rate Constant given Area under Curve

Go Elimination Rate Constant = Dose/(Area Under Curve*Volume of Distribution)

Elimination Rate Constant given Volume of Plasma Cleared

Go Elimination Rate Constant = Volume of Plasma Cleared/Volume of Distribution

Elimination Rate Constant of Drug

Go Elimination Rate Constant = ln(2)/Elimination Half Life

Elimination Half Life of Drug

Go Elimination Half Life = ln(2)/Elimination Rate Constant

Total Clearance of Body Formula

Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance
CL_total = CL_hepatic+CL_renal+CL_pulmonary+CL_other

What are main clearance organs?

CLhepatic: This is the clearance of a drug by the liver. The liver is a major organ for drug metabolism, and it is responsible for breaking down and eliminating many drugs from the body.
CLrenal: This is the clearance of a drug by the kidneys. The kidneys are responsible for filtering out drugs from the blood, and they are a major route of drug elimination.
CLpulmonary: This is the clearance of a drug by the lungs. The lungs are responsible for exchanging gases in the blood, and they can also eliminate some drugs from the body.
CLother: This is the clearance of a drug by other organs or tissues. There are a number of other organs and tissues that can contribute to the clearance of drugs, such as the gut, the brain, and the skin.

How to Calculate Total Clearance of Body?

Total Clearance of Body calculator uses Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance to calculate the Total Clearance, The Total Clearance of Body formula is defined as is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body. Total Clearance is denoted by CL_total symbol.

How to calculate Total Clearance of Body using this online calculator? To use this online calculator for Total Clearance of Body, enter Hepatic Clearance (CL_hepatic), Renal Clearance for Total (CL_renal), Pulmonary Clearance (CL_pulmonary) & Other Clearance (CL_other) and hit the calculate button. Here is how the Total Clearance of Body calculation can be explained with given input values -> 1.9E+7 = 4.16666666666667E-07+5.55555555555556E-07+4.16666666666667E-07+5.55555555555556E-08.

FAQ

What is Total Clearance of Body?

The Total Clearance of Body formula is defined as is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body and is represented as CL_total = CL_hepatic+CL_renal+CL_pulmonary+CL_other or Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance. The Hepatic Clearance is the clearance of a drug by the liver. The liver is a major organ for drug metabolism, and it is responsible for breaking down and eliminating many drugs from the body, The Renal Clearance for Total is the clearance of a drug by the kidneys. The kidneys are responsible for filtering out drugs from the blood, and they are a major route of drug elimination, The Pulmonary Clearance is the clearance of a drug by the lungs. The lungs are responsible for exchanging gases in the blood, and they can also eliminate some drugs from the body & The Other Clearance is the clearance of a drug by other organs or tissues. There are organs and tissues that can contribute to the clearance of drugs, such as the gut, the brain, and the skin.

How to calculate Total Clearance of Body?

The Total Clearance of Body formula is defined as is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body is calculated using Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance. To calculate Total Clearance of Body, you need Hepatic Clearance (CL_hepatic), Renal Clearance for Total (CL_renal), Pulmonary Clearance (CL_pulmonary) & Other Clearance (CL_other). With our tool, you need to enter the respective value for Hepatic Clearance, Renal Clearance for Total, Pulmonary Clearance & Other Clearance and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

Home

FREE PDFs

🔍 Search