What is Pharmacokinetics?
Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.
How to Calculate Volume of Distribution given Area under Curve?
Volume of Distribution given Area under Curve calculator uses Volume of Distribution = Dose/(Elimination Rate Constant*Area Under Curve) to calculate the Volume of Distribution, The Volume of Distribution given Area under Curve formula is defined as the ratio of the amount of drug administered to the elimination rate constant and area under the curve of the concentration-time graph. Volume of Distribution is denoted by V_{d} symbol.
How to calculate Volume of Distribution given Area under Curve using this online calculator? To use this online calculator for Volume of Distribution given Area under Curve, enter Dose (D), Elimination Rate Constant (k_{e}) & Area Under Curve (AUC) and hit the calculate button. Here is how the Volume of Distribution given Area under Curve calculation can be explained with given input values -> 376175.5 = 8/(1.61111111111111E-05*1320).