Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood Calculator

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Volume of Distribution

Area under curve

Bioavailability

Dose

Drug Content

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of plasma cleared

✖Plasma Volume is the measurement in which a drug is distributed in blood plasma.ⓘ Plasma Volume [V_P]			+10% -10%
✖Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.ⓘ Apparent Tissue Volume [V_T]			+10% -10%
✖Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.ⓘ Fraction Unbound in Plasma [fu]			+10% -10%
✖Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.ⓘ Fraction Unbound in Tissue [fu_t]			+10% -10%

✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood [V_d]

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Formula

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Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood

Formula

`"V"_{"d"} = "V"_{"P"}+("V"_{"T"}*("fu"/"fu"_{"t"}))`

Example

`"9.95L"="5L"+("3.5L"*("0.99"/"0.7"))`

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Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood Solution

STEP 0: Pre-Calculation Summary

Formula Used

Volume of Distribution = Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
V_d = V_P+(V_T*(fu/fu_t))
This formula uses 5 Variables

Variables Used

Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Plasma Volume - (Measured in Cubic Meter) - Plasma Volume is the measurement in which a drug is distributed in blood plasma.
Apparent Tissue Volume - (Measured in Cubic Meter) - Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.
Fraction Unbound in Plasma - Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.
Fraction Unbound in Tissue - Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.

STEP 1: Convert Input(s) to Base Unit

Plasma Volume: 5 Liter --> 0.005 Cubic Meter (Check conversion here)
Apparent Tissue Volume: 3.5 Liter --> 0.0035 Cubic Meter (Check conversion here)
Fraction Unbound in Plasma: 0.99 --> No Conversion Required
Fraction Unbound in Tissue: 0.7 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V_d = V_P+(V_T*(fu/fu_t)) --> 0.005+(0.0035*(0.99/0.7))

Evaluating ... ...

V_d = 0.00995

STEP 3: Convert Result to Output's Unit

0.00995 Cubic Meter -->9.95 Liter (Check conversion here)

FINAL ANSWER

9.95 Liter <-- Volume of Distribution

(Calculation completed in 00.020 seconds)

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< 5 Volume of Distribution Calculators

Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood

Go Volume of Distribution = Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))

Volume of Distribution given Elimination Half Life

Go Volume of Distribution = (Volume of Plasma Cleared*Elimination Half Life)/ln(2)

Volume of Distribution given Area under Curve

Go Volume of Distribution = Dose/(Elimination Rate Constant*Area Under Curve)

Volume of Distribution in Clearance of Drug

Go Volume of distribution clearance = Elimination Rate Constant Drug/Clearance Of Drug

Volume of Distribution given Volume of Plasma Cleared

Go Volume of Distribution = Volume of Plasma Cleared/Elimination Half Life

Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood Formula

Volume of Distribution = Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
V_d = V_P+(V_T*(fu/fu_t))

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood?

Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood calculator uses Volume of Distribution = Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)) to calculate the Volume of Distribution, The Volume of distribution of drug displacing into body tissue relative to blood formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue. Volume of Distribution is denoted by V_d symbol.

How to calculate Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood using this online calculator? To use this online calculator for Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood, enter Plasma Volume (V_P), Apparent Tissue Volume (V_T), Fraction Unbound in Plasma (fu) & Fraction Unbound in Tissue (fu_t) and hit the calculate button. Here is how the Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood calculation can be explained with given input values -> 9950 = 0.005+(0.0035*(0.99/0.7)).

FAQ

What is Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood?

The Volume of distribution of drug displacing into body tissue relative to blood formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue and is represented as V_d = V_P+(V_T*(fu/fu_t)) or Volume of Distribution = Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)). Plasma Volume is the measurement in which a drug is distributed in blood plasma, Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue, Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma & Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.

How to calculate Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood?

The Volume of distribution of drug displacing into body tissue relative to blood formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue is calculated using Volume of Distribution = Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)). To calculate Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood, you need Plasma Volume (V_P), Apparent Tissue Volume (V_T), Fraction Unbound in Plasma (fu) & Fraction Unbound in Tissue (fu_t). With our tool, you need to enter the respective value for Plasma Volume, Apparent Tissue Volume, Fraction Unbound in Plasma & Fraction Unbound in Tissue and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Volume of Distribution?

In this formula, Volume of Distribution uses Plasma Volume, Apparent Tissue Volume, Fraction Unbound in Plasma & Fraction Unbound in Tissue. We can use 3 other way(s) to calculate the same, which is/are as follows -

Volume of Distribution = Volume of Plasma Cleared/Elimination Half Life
Volume of Distribution = (Volume of Plasma Cleared*Elimination Half Life)/ln(2)
Volume of Distribution = Dose/(Elimination Rate Constant*Area Under Curve)

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