What is Pharmacokinetics?
Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.
How to Calculate Volume of Distribution given Elimination Half Life?
Volume of Distribution given Elimination Half Life calculator uses Volume of Distribution = (Volume of Plasma Cleared*Elimination Half Life)/ln(2) to calculate the Volume of Distribution, The Volume of distribution given elimination half life formula is defined as the direct relation with the product of the volume of plasma cleared of the drug per unit time and time required for the concentration of the drug to reach half of its original value. Volume of Distribution is denoted by V_{d} symbol.
How to calculate Volume of Distribution given Elimination Half Life using this online calculator? To use this online calculator for Volume of Distribution given Elimination Half Life, enter Volume of Plasma Cleared (CL) & Elimination Half Life (t_{b/2}) and hit the calculate button. Here is how the Volume of Distribution given Elimination Half Life calculation can be explained with given input values -> 8309.923 = (0.00048*12)/ln(2).