Area under Curve given Volume of Plasma Cleared Calculator

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Area under curve

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Elimination Rate Constant

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Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Dose is the amount of drug administered.ⓘ Dose [D]			+10% -10%
✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared [CL]			+10% -10%

✖Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.ⓘ Area under Curve given Volume of Plasma Cleared [AUC]

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Formula

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Area under Curve given Volume of Plasma Cleared

Formula

`"AUC" = "D"/"CL"`

Example

`"16.66667mol*s/L"="8mol"/"0.48L/s"`

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Area under Curve given Volume of Plasma Cleared Solution

STEP 0: Pre-Calculation Summary

Formula Used

Area Under Curve = Dose/Volume of Plasma Cleared
AUC = D/CL
This formula uses 3 Variables

Variables Used

Area Under Curve - (Measured in Mole Second per Cubic Meter) - Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.
Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

STEP 1: Convert Input(s) to Base Unit

Dose: 8 Mole --> 8 Mole No Conversion Required
Volume of Plasma Cleared: 0.48 Liter per Second --> 0.00048 Cubic Meter per Second (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

AUC = D/CL --> 8/0.00048

Evaluating ... ...

AUC = 16666.6666666667

STEP 3: Convert Result to Output's Unit

16666.6666666667 Mole Second per Cubic Meter -->16.6666666666667 Mole Second per Liter (Check conversion here)

FINAL ANSWER

16.6666666666667 ≈ 16.66667 Mole Second per Liter <-- Area Under Curve

(Calculation completed in 00.020 seconds)

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K J Somaiya College of science (K J Somaiya), Mumbai

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< 8 Area under curve Calculators

Area under Curve for Drug Administered Intravenous

Go Area under Curve Intravenous = (Area under Curve Non-Intravenous*Dose Intravenous)/(Bioavailability of Drug*Dose Non-Intravenous)

Area under Curve for Drug Administered Orally

Go Area under Curve Non-Intravenous = (Bioavailability of Drug*Area under Curve Intravenous*Dose Non-Intravenous)/Dose Intravenous

Area under Curve of Drug for Dosage Type A

Go Area under curve Dosage A = (Relative Bioavailability*Area under curve Dosage B)*(Dose Type A/Dose Type B)

Area under Curve of Drug for Dosage Type B

Go Area under curve Dosage B = (Area under curve Dosage A/Relative Bioavailability)*(Dose Type B/Dose Type A)

Area under Curve given Dose and Volume of Distribution

Go Area Under Curve = Dose/(Volume of Distribution*Elimination Rate Constant)

Area under Curve Given Average Plasma Concentration

Go Area Under Curve = Average Plasma Concentration*Dosing Interval

Average Plasma Concentration given Area under Curve

Go Average Plasma Concentration = Area Under Curve/Dosing Interval

Area under Curve given Volume of Plasma Cleared

Go Area Under Curve = Dose/Volume of Plasma Cleared

Area under Curve given Volume of Plasma Cleared Formula

Area Under Curve = Dose/Volume of Plasma Cleared
AUC = D/CL

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Area under Curve given Volume of Plasma Cleared?

Area under Curve given Volume of Plasma Cleared calculator uses Area Under Curve = Dose/Volume of Plasma Cleared to calculate the Area Under Curve, The Area under Curve given Volume of Plasma Cleared formula is defined as the ratio of the amount of drug administered to the volume of plasma cleared of the drug per unit time. Area Under Curve is denoted by AUC symbol.

How to calculate Area under Curve given Volume of Plasma Cleared using this online calculator? To use this online calculator for Area under Curve given Volume of Plasma Cleared, enter Dose (D) & Volume of Plasma Cleared (CL) and hit the calculate button. Here is how the Area under Curve given Volume of Plasma Cleared calculation can be explained with given input values -> 0.016667 = 8/0.00048.

FAQ

What is Area under Curve given Volume of Plasma Cleared?

The Area under Curve given Volume of Plasma Cleared formula is defined as the ratio of the amount of drug administered to the volume of plasma cleared of the drug per unit time and is represented as AUC = D/CL or Area Under Curve = Dose/Volume of Plasma Cleared. The Dose is the amount of drug administered & The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

How to calculate Area under Curve given Volume of Plasma Cleared?

The Area under Curve given Volume of Plasma Cleared formula is defined as the ratio of the amount of drug administered to the volume of plasma cleared of the drug per unit time is calculated using Area Under Curve = Dose/Volume of Plasma Cleared. To calculate Area under Curve given Volume of Plasma Cleared, you need Dose (D) & Volume of Plasma Cleared (CL). With our tool, you need to enter the respective value for Dose & Volume of Plasma Cleared and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Area Under Curve?

In this formula, Area Under Curve uses Dose & Volume of Plasma Cleared. We can use 2 other way(s) to calculate the same, which is/are as follows -

Area Under Curve = Dose/(Volume of Distribution*Elimination Rate Constant)
Area Under Curve = Average Plasma Concentration*Dosing Interval

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