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Dissociation Constant of Enzyme given Modifying Factor of Enzyme Calculator

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✖The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.ⓘ Inhibitor Concentration [I]
+10%
-10%
✖The Enzyme Modifying Factor is defined by the inhibitor concentration and the dissociation constants of enzyme.ⓘ Enzyme Modifying Factor [α]
+10%
-10%
✖Enzyme Inhibitor Dissociation Constant given MF is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.ⓘ Dissociation Constant of Enzyme given Modifying Factor of Enzyme [Kei]
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Dissociation Constant of Enzyme given Modifying Factor of Enzyme

Formula
`"K"_{"ei"} = "I"/("α"-1)`

Example
`"2.25mol/L"="9mol/L"/("5"-1)`

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Dissociation Constant of Enzyme given Modifying Factor of Enzyme Solution

STEP 0: Pre-Calculation Summary
Formula Used
Enzyme Inhibitor Dissociation Constant given MF = Inhibitor Concentration/(Enzyme Modifying Factor-1)
Kei = I/(α-1)
This formula uses 3 Variables
Variables Used
Enzyme Inhibitor Dissociation Constant given MF - (Measured in Mole per Cubic Meter) - Enzyme Inhibitor Dissociation Constant given MF is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.
Inhibitor Concentration - (Measured in Mole per Cubic Meter) - The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.
Enzyme Modifying Factor - The Enzyme Modifying Factor is defined by the inhibitor concentration and the dissociation constants of enzyme.
STEP 1: Convert Input(s) to Base Unit
Inhibitor Concentration: 9 Mole per Liter --> 9000 Mole per Cubic Meter (Check conversion here)
Enzyme Modifying Factor: 5 --> No Conversion Required
STEP 2: Evaluate Formula
Substituting Input Values in Formula
Kei = I/(α-1) --> 9000/(5-1)
Evaluating ... ...
Kei = 2250
STEP 3: Convert Result to Output's Unit
2250 Mole per Cubic Meter -->2.25 Mole per Liter (Check conversion here)
FINAL ANSWER
2.25 Mole per Liter <-- Enzyme Inhibitor Dissociation Constant given MF
(Calculation completed in 00.004 seconds)
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Created by Prashant Singh
K J Somaiya College of science (K J Somaiya), Mumbai
Prashant Singh has created this Calculator and 700+ more calculators!
Verified by Prerana Bakli
University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA
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23 Competitive Inhibitor Calculators

Final Rate Constant for Competitive Inhibition of Enzyme Catalysis
Go Final Rate Constant for Catalysis = (Initial Reaction Rate*(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration))/(Initial Enzyme Concentration*Substrate Concentration)
Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis
Go Inhibitor Concentration given IEC = (((((Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant
Initial Enzyme Concentration of Competitive Inhibition of Enzyme Catalysis
Go Initial Enzyme Concentration = (Initial Reaction Rate*(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration))/(Final Rate Constant*Substrate Concentration)
Substrate Concentration of Competitive Inhibition of Enzyme Catalysis
Go Substrate Concentration = (Initial Reaction Rate*(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))))/((Final Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate)
Dissociation Constant for Competitive Inhibition of Enzyme Catalysis
Go Enzyme Inhibitor Dissociation Constant = Inhibitor Concentration/(((((Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)
Michaelis Constant for Competitive Inhibition of Enzyme Catalysis
Go Michaelis Constant = (((Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))
Initial Rate of System of Competitive Inhibition of Enzyme Catalysis
Go Initial Reaction Rate = (Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration)
Substrate Concentration given Modifying Factor in Michaelis Menten Equation
Go Substrate Concentration = (Initial Reaction Rate*(Enzyme Modifying Factor/Enzyme Substrate Modifying Factor)*Michaelis Constant)/(((1/Enzyme Substrate Modifying Factor)*Maximum Rate)-Initial Reaction Rate)
Substrate Concentration in Competitive Inhibition given Enzyme Substrate Complex Concentration
Go Substrate Concentration = (Enzyme Substrate Complex Concentration*(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))))/((Initial Enzyme Concentration)-Enzyme Substrate Complex Concentration)
Inhibitor Concentration in Competitive Inhibition given Enzyme Substrate Complex Concentration
Go Inhibitor Concentration = (((((Initial Enzyme Concentration*Substrate Concentration)/Enzyme Substrate Complex Concentration)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant
Michaelis Constant in Competitive Inhibition given Enzyme Substrate Complex Concentration
Go Michaelis Constant = (((Initial Enzyme Concentration*Substrate Concentration)/Enzyme Substrate Complex Concentration)-Substrate Concentration)/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))
Initial Enzyme in Competitive Inhibition given Enzyme Substrate Complex Concentration
Go Initial Enzyme Concentration = (Enzyme Substrate Complex Concentration*(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration))/(Substrate Concentration)
Enzyme Substrate Complex Concentration for Competitive Inhibition of Enzyme Catalysis
Go Enzyme Substrate Complex Concentration = (Substrate Concentration*Initial Enzyme Concentration)/(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration)
Inhibitor Concentration in Competitive Inhibition given Maximum Rate of System
Go Inhibitor Concentration given Max Rate = (((((Maximum Rate*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant
Initial Rate in Competitive Inhibition given Maximum Rate of system
Go Initial Reaction Rate in CI = (Maximum Rate*Substrate Concentration)/(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration)
Dissociation Constant in Competitive Inhibition given Maximum Rate of System
Go Enzyme Inhibitor Dissociation Constant = Inhibitor Concentration/(((((Maximum Rate*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)
Michaelis Constant in Competitive Inhibition given Maximum Rate of System
Go Michaelis Constant = (((Maximum Rate*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))
Substrate Concentration in Competitive Inhibition given Maximum Rate of System
Go Substrate Concentration = (Initial Reaction Rate*(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))))/(Maximum Rate-Initial Reaction Rate)
Apparent Value of Michaelis Menten Constant in Presence of Competitive Inhibition
Go Apparent Michaelis Constant = (Substrate Concentration*(Maximum Rate-Initial Reaction Rate))/Initial Reaction Rate
Substrate Concentration given Apparent value of Michaelis Menten Constant
Go Substrate Concentration = (Apparent Michaelis Constant*Initial Reaction Rate)/(Maximum Rate-Initial Reaction Rate)
Dissociation Constant of Enzyme Substrate Complex given Modifying Factor of Enzyme Substrate
Go Enzyme Substrate Dissociation Constant = Inhibitor Concentration/(Enzyme Substrate Modifying Factor-1)
Dissociation Constant of Enzyme given Modifying Factor of Enzyme
Go Enzyme Inhibitor Dissociation Constant given MF = Inhibitor Concentration/(Enzyme Modifying Factor-1)
Modifying Factor of Enzyme
Go Enzyme Modifying Factor = 1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant)

25 Important Formulas on Enzyme Kinetics Calculators

Final Rate Constant for Competitive Inhibition of Enzyme Catalysis
Go Final Rate Constant for Catalysis = (Initial Reaction Rate*(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration))/(Initial Enzyme Concentration*Substrate Concentration)
Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis
Go Inhibitor Concentration given IEC = (((((Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant
Michaelis Constant in Competitive Inhibition given Enzyme Substrate Complex Concentration
Go Michaelis Constant = (((Initial Enzyme Concentration*Substrate Concentration)/Enzyme Substrate Complex Concentration)-Substrate Concentration)/(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))
Enzyme Substrate Complex Concentration for Competitive Inhibition of Enzyme Catalysis
Go Enzyme Substrate Complex Concentration = (Substrate Concentration*Initial Enzyme Concentration)/(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration)
Inhibitor Concentration in Competitive Inhibition given Maximum Rate of System
Go Inhibitor Concentration given Max Rate = (((((Maximum Rate*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant
Initial Rate in Competitive Inhibition given Maximum Rate of system
Go Initial Reaction Rate in CI = (Maximum Rate*Substrate Concentration)/(Michaelis Constant*(1+(Inhibitor Concentration/Enzyme Inhibitor Dissociation Constant))+Substrate Concentration)
Enzyme Catalyst Concentration given Forward, Reverse, and Catalytic Rate Constants
Go Catalyst Concentration = ((Reverse Rate Constant+Catalytic Rate Constant)*Enzyme Substrate Complex Concentration)/(Forward Rate Constant*Substrate Concentration)
Catalytic Rate Constant from Michaelis Menten Kinetics Equation
Go Catalytic Rate Constant for MM = (Initial Reaction Rate*(Michaelis Constant+Substrate Concentration))/(Initial Enzyme Concentration*Substrate Concentration)
Enzyme Concentration from Michaelis Menten Kinetics equation
Go Initial Concentration of Enzyme = (Initial Reaction Rate*(Michaelis Constant+Substrate Concentration))/(Catalytic Rate Constant*Substrate Concentration)
Substrate Concentration given Catalytic Rate Constant and Initial Enzyme Concentration
Go Concentration of Substrate = (Michaelis Constant*Initial Reaction Rate)/((Catalytic Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate)
Initial Enzyme Concentration given Dissociation Rate Constant
Go Enzyme Concentration Initially = (Enzyme Substrate Complex Concentration*(Dissociation Rate Constant+Substrate Concentration))/(Substrate Concentration)
Initial Reaction Rate given Dissociation Rate Constant
Go Initial Reaction Rate given DRC = (Maximum Rate*Substrate Concentration)/(Dissociation Rate Constant+Substrate Concentration)
Maximum Rate given Dissociation Rate Constant
Go Maximum Rate given DRC = (Initial Reaction Rate*(Dissociation Rate Constant+Substrate Concentration))/Substrate Concentration
Inhibitor Concentration given Apparent Initial Enzyme Concentration
Go Inhibitor Concentration for CI = ((Initial Enzyme Concentration/Apparent Initial Enzyme Concentration)-1)*Enzyme Inhibitor Dissociation Constant
Initial Concentration of Enzyme in presence of Inhibitor by Enzyme Conservation Law
Go Enzyme Concentration Initially = (Catalyst Concentration+Enzyme Substrate Complex Concentration+Enzyme Inhibitor Complex Concentration)
Michaelis Constant given Forward, Reverse, and Catalytic Rate Constants
Go Michaelis Constant = (Reverse Rate Constant+Catalytic Rate Constant)/Forward Rate Constant
Inhibitor Concentration given Enzyme Substrate Modifying Factor
Go Inhibitor Concentration = (Enzyme Substrate Modifying Factor-1)*Enzyme Substrate Dissociation Constant
Modifying Factor of Enzyme Substrate Complex
Go Enzyme Substrate Modifying Factor = 1+(Inhibitor Concentration/Enzyme Substrate Dissociation Constant)
Dissociation Constant of Enzyme given Modifying Factor of Enzyme
Go Enzyme Inhibitor Dissociation Constant given MF = Inhibitor Concentration/(Enzyme Modifying Factor-1)
Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration
Go Initial Reaction Rate given RC = Final Rate Constant*Enzyme Substrate Complex Concentration
Forward Rate Constant given Dissociation Rate Constant
Go Forward Rate Constant = (Reverse Rate Constant/Dissociation Rate Constant)
Dissociation Rate Constant in Enzymatic Reaction Mechanism
Go Dissociation Rate Constant = Reverse Rate Constant/Forward Rate Constant
Initial Enzyme Concentration if Substrate Concentration is Higher than Michaelis Constant
Go Enzyme Concentration Initially = Maximum Rate/Catalytic Rate Constant
Catalytic Rate Constant if Substrate Concentration is higher than Michaelis Constant
Go Catalytic Rate Constant = Maximum Rate/Initial Enzyme Concentration
Maximum Rate if Substrate Concentration is Higher than Michaelis Constant
Go Maximum Rate = Catalytic Rate Constant*Initial Enzyme Concentration

Dissociation Constant of Enzyme given Modifying Factor of Enzyme Formula

Enzyme Inhibitor Dissociation Constant given MF = Inhibitor Concentration/(Enzyme Modifying Factor-1)
Kei = I/(α-1)

What is dissociation constant?

The dissociation constant (Kd) quantifies the equilibrium between a ligand (L) being free in solution and bound to a site in a protein (EL). It corresponds to the affinity which the ligand has for the binding site. Ligands with higher, more favorable free energy of association bind “tighter” and therefore have greater preference for the bound state. Because Kd is defined as a dissociation constant, higher affinity ligands have lower Kd values.

What is competitive Inhibition?

In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time,this usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate and inhibitor compete for access to the enzyme's active site.This type of inhibition can overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. However, the apparent Km will increase as it takes a higher concentration of the substrate to reach the Km point, or half the Vmax. Competitive inhibitors are often similar in structure to the real substrate.

How to Calculate Dissociation Constant of Enzyme given Modifying Factor of Enzyme?

Dissociation Constant of Enzyme given Modifying Factor of Enzyme calculator uses Enzyme Inhibitor Dissociation Constant given MF = Inhibitor Concentration/(Enzyme Modifying Factor-1) to calculate the Enzyme Inhibitor Dissociation Constant given MF, The Dissociation constant of enzyme given modifying factor of enzyme formula is defined as the relation with the inhibitor concentration and with the modifying factor of the enzyme. Enzyme Inhibitor Dissociation Constant given MF is denoted by Kei symbol.

How to calculate Dissociation Constant of Enzyme given Modifying Factor of Enzyme using this online calculator? To use this online calculator for Dissociation Constant of Enzyme given Modifying Factor of Enzyme, enter Inhibitor Concentration (I) & Enzyme Modifying Factor (α) and hit the calculate button. Here is how the Dissociation Constant of Enzyme given Modifying Factor of Enzyme calculation can be explained with given input values -> 2250 = 9000/(5-1).

FAQ

What is Dissociation Constant of Enzyme given Modifying Factor of Enzyme?
The Dissociation constant of enzyme given modifying factor of enzyme formula is defined as the relation with the inhibitor concentration and with the modifying factor of the enzyme and is represented as Kei = I/(α-1) or Enzyme Inhibitor Dissociation Constant given MF = Inhibitor Concentration/(Enzyme Modifying Factor-1). The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system & The Enzyme Modifying Factor is defined by the inhibitor concentration and the dissociation constants of enzyme.
How to calculate Dissociation Constant of Enzyme given Modifying Factor of Enzyme?
The Dissociation constant of enzyme given modifying factor of enzyme formula is defined as the relation with the inhibitor concentration and with the modifying factor of the enzyme is calculated using Enzyme Inhibitor Dissociation Constant given MF = Inhibitor Concentration/(Enzyme Modifying Factor-1). To calculate Dissociation Constant of Enzyme given Modifying Factor of Enzyme, you need Inhibitor Concentration (I) & Enzyme Modifying Factor (α). With our tool, you need to enter the respective value for Inhibitor Concentration & Enzyme Modifying Factor and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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