Elimination Half Life given Volume of Plasma Cleared Calculator

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Elimination Rate Constant

Area under curve

Bioavailability

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%
✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared [CL]			+10% -10%

✖Elimination Half Life is the time required for the concentration of the drug to reach half of its original value.ⓘ Elimination Half Life given Volume of Plasma Cleared [t_b/2]

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Formula

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Elimination Half Life given Volume of Plasma Cleared

Formula

`"t"_{"b/2"} = (ln(2)*"V"_{"d"})/"CL"`

Example

`"12.99651s"=(ln(2)*"9L")/"0.48L/s"`

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Elimination Half Life given Volume of Plasma Cleared Solution

STEP 0: Pre-Calculation Summary

Formula Used

Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared
t_b/2 = (ln(2)*V_d)/CL
This formula uses 1 Functions, 3 Variables

Functions Used

ln - The natural logarithm, also known as the logarithm to the base e, is the inverse function of the natural exponential function., ln(Number)

Variables Used

Elimination Half Life - (Measured in Second) - Elimination Half Life is the time required for the concentration of the drug to reach half of its original value.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

STEP 1: Convert Input(s) to Base Unit

Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
Volume of Plasma Cleared: 0.48 Liter per Second --> 0.00048 Cubic Meter per Second (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

t_b/2 = (ln(2)*V_d)/CL --> (ln(2)*0.009)/0.00048

Evaluating ... ...

t_b/2 = 12.996509635499

STEP 3: Convert Result to Output's Unit

12.996509635499 Second --> No Conversion Required

FINAL ANSWER

12.996509635499 ≈ 12.99651 Second <-- Elimination Half Life

(Calculation completed in 00.020 seconds)

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< 6 Elimination Rate Constant Calculators

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Go Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance

Elimination Half Life given Volume of Plasma Cleared

Go Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared

Elimination Rate Constant given Area under Curve

Go Elimination Rate Constant = Dose/(Area Under Curve*Volume of Distribution)

Elimination Rate Constant given Volume of Plasma Cleared

Go Elimination Rate Constant = Volume of Plasma Cleared/Volume of Distribution

Elimination Rate Constant of Drug

Go Elimination Rate Constant = ln(2)/Elimination Half Life

Elimination Half Life of Drug

Go Elimination Half Life = ln(2)/Elimination Rate Constant

Elimination Half Life given Volume of Plasma Cleared Formula

Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared
t_b/2 = (ln(2)*V_d)/CL

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Elimination Half Life given Volume of Plasma Cleared?

Elimination Half Life given Volume of Plasma Cleared calculator uses Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared to calculate the Elimination Half Life, The Elimination half life given volume of plasma cleared formula is defined as the direct relation with the apparent volume in which a drug is distributed and an inverse relationship with the volume of plasma cleared of the drug per unit time. Elimination Half Life is denoted by t_b/2 symbol.

How to calculate Elimination Half Life given Volume of Plasma Cleared using this online calculator? To use this online calculator for Elimination Half Life given Volume of Plasma Cleared, enter Volume of Distribution (V_d) & Volume of Plasma Cleared (CL) and hit the calculate button. Here is how the Elimination Half Life given Volume of Plasma Cleared calculation can be explained with given input values -> 12.99651 = (ln(2)*0.009)/0.00048.

FAQ

What is Elimination Half Life given Volume of Plasma Cleared?

The Elimination half life given volume of plasma cleared formula is defined as the direct relation with the apparent volume in which a drug is distributed and an inverse relationship with the volume of plasma cleared of the drug per unit time and is represented as t_b/2 = (ln(2)*V_d)/CL or Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared. The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body & The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

How to calculate Elimination Half Life given Volume of Plasma Cleared?

The Elimination half life given volume of plasma cleared formula is defined as the direct relation with the apparent volume in which a drug is distributed and an inverse relationship with the volume of plasma cleared of the drug per unit time is calculated using Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared. To calculate Elimination Half Life given Volume of Plasma Cleared, you need Volume of Distribution (V_d) & Volume of Plasma Cleared (CL). With our tool, you need to enter the respective value for Volume of Distribution & Volume of Plasma Cleared and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Elimination Half Life?

In this formula, Elimination Half Life uses Volume of Distribution & Volume of Plasma Cleared. We can use 1 other way(s) to calculate the same, which is/are as follows -

Elimination Half Life = ln(2)/Elimination Rate Constant

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