Fraction of Drug Unbound in Plasma given Plasma Volume Calculator

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Volume of plasma cleared

Area under curve

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of Distribution

✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%
✖Plasma Volume is the measurement in which a drug is distributed in blood plasma.ⓘ Plasma Volume [V_P]			+10% -10%
✖Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.ⓘ Apparent Tissue Volume [V_T]			+10% -10%
✖Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.ⓘ Fraction Unbound in Tissue [fu_t]			+10% -10%

✖Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.ⓘ Fraction of Drug Unbound in Plasma given Plasma Volume [fu]

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Formula

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Fraction of Drug Unbound in Plasma given Plasma Volume

Formula

`"fu" = (("V"_{"d"}-"V"_{"P"})/"V"_{"T"})*"fu"_{"t"}`

Example

`"0.8"=(("9L"-"5L")/"3.5L")*"0.7"`

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Fraction of Drug Unbound in Plasma given Plasma Volume Solution

STEP 0: Pre-Calculation Summary

Formula Used

Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue
fu = ((V_d-V_P)/V_T)*fu_t
This formula uses 5 Variables

Variables Used

Fraction Unbound in Plasma - Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Plasma Volume - (Measured in Cubic Meter) - Plasma Volume is the measurement in which a drug is distributed in blood plasma.
Apparent Tissue Volume - (Measured in Cubic Meter) - Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.
Fraction Unbound in Tissue - Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.

STEP 1: Convert Input(s) to Base Unit

Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
Plasma Volume: 5 Liter --> 0.005 Cubic Meter (Check conversion here)
Apparent Tissue Volume: 3.5 Liter --> 0.0035 Cubic Meter (Check conversion here)
Fraction Unbound in Tissue: 0.7 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

fu = ((V_d-V_P)/V_T)*fu_t --> ((0.009-0.005)/0.0035)*0.7

Evaluating ... ...

fu = 0.8

STEP 3: Convert Result to Output's Unit

0.8 --> No Conversion Required

FINAL ANSWER

0.8 <-- Fraction Unbound in Plasma

(Calculation completed in 00.004 seconds)

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< 5 Volume of plasma cleared Calculators

Fraction of Drug Unbound in Plasma given Plasma Volume

Go Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue

Volume of Plasma Cleared given Elimination Half Life

Go Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life

Volume of Plasma Cleared of Drug given Rate at which Drug is Removed

Go Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution

Volume of Plasma Cleared given Rate of Infusion

Go Volume of Plasma Cleared = Rate of Infusion/Concentration of Drug

Volume of Plasma Cleared given Area under Curve

Go Volume of Plasma Cleared = Dose/Area Under Curve

Fraction of Drug Unbound in Plasma given Plasma Volume Formula

Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue
fu = ((V_d-V_P)/V_T)*fu_t

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Fraction of Drug Unbound in Plasma given Plasma Volume?

Fraction of Drug Unbound in Plasma given Plasma Volume calculator uses Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue to calculate the Fraction Unbound in Plasma, The Fraction of drug unbound in plasma given plasma volume formula is defined as the systemically available fraction of a drug in blood plasma with respect to body tissue. Fraction Unbound in Plasma is denoted by fu symbol.

How to calculate Fraction of Drug Unbound in Plasma given Plasma Volume using this online calculator? To use this online calculator for Fraction of Drug Unbound in Plasma given Plasma Volume, enter Volume of Distribution (V_d), Plasma Volume (V_P), Apparent Tissue Volume (V_T) & Fraction Unbound in Tissue (fu_t) and hit the calculate button. Here is how the Fraction of Drug Unbound in Plasma given Plasma Volume calculation can be explained with given input values -> 0.8 = ((0.009-0.005)/0.0035)*0.7.

FAQ

What is Fraction of Drug Unbound in Plasma given Plasma Volume?

The Fraction of drug unbound in plasma given plasma volume formula is defined as the systemically available fraction of a drug in blood plasma with respect to body tissue and is represented as fu = ((V_d-V_P)/V_T)*fu_t or Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue. The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body, Plasma Volume is the measurement in which a drug is distributed in blood plasma, Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue & Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.

How to calculate Fraction of Drug Unbound in Plasma given Plasma Volume?

The Fraction of drug unbound in plasma given plasma volume formula is defined as the systemically available fraction of a drug in blood plasma with respect to body tissue is calculated using Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue. To calculate Fraction of Drug Unbound in Plasma given Plasma Volume, you need Volume of Distribution (V_d), Plasma Volume (V_P), Apparent Tissue Volume (V_T) & Fraction Unbound in Tissue (fu_t). With our tool, you need to enter the respective value for Volume of Distribution, Plasma Volume, Apparent Tissue Volume & Fraction Unbound in Tissue and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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