Relative Bioavailability of Drug Solution

STEP 0: Pre-Calculation Summary
Formula Used
Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)
Frel = (AUCdosageA/AUCdosageB)*(DB/DA)
This formula uses 5 Variables
Variables Used
Relative Bioavailability - Relative Bioavailability compares the bioavailability between two different dosage forms.
Area under curve Dosage A - (Measured in Mole Second per Cubic Meter) - The Area under curve Dosage A is the integral of the concentration-time curve for A form of dosage.
Area under curve Dosage B - (Measured in Mole Second per Cubic Meter) - The Area under curve Dosage B is the integral of the concentration-time curve for B form of dosage.
Dose Type B - (Measured in Mole) - Dose Type B is the amount of drug administered in B-type dosage form.
Dose Type A - (Measured in Mole) - Dose Type A is the amount of drug administered in A-type dosage form.
STEP 1: Convert Input(s) to Base Unit
Area under curve Dosage A: 1.141 Mole Second per Liter --> 1141 Mole Second per Cubic Meter (Check conversion here)
Area under curve Dosage B: 1.732 Mole Second per Liter --> 1732 Mole Second per Cubic Meter (Check conversion here)
Dose Type B: 15 Mole --> 15 Mole No Conversion Required
Dose Type A: 11.5 Mole --> 11.5 Mole No Conversion Required
STEP 2: Evaluate Formula
Substituting Input Values in Formula
Frel = (AUCdosageA/AUCdosageB)*(DB/DA) --> (1141/1732)*(15/11.5)
Evaluating ... ...
Frel = 0.859273019379456
STEP 3: Convert Result to Output's Unit
0.859273019379456 --> No Conversion Required
FINAL ANSWER
0.859273019379456 0.859273 <-- Relative Bioavailability
(Calculation completed in 00.020 seconds)

Credits

Created by Prashant Singh
K J Somaiya College of science (K J Somaiya), Mumbai
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25 Drug Content Calculators

Saponification value
Go Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken
Fraction of Drug Unbound in Tissue given Apparent Tissue Volume
Go Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)
Secretion Rate of Drug
Go Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)
Reabsorption Rate of Drug
Go Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)
Filtration Rate of Drug
Go Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)
Relative Bioavailability of Drug
Go Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)
Acid Value of KOH
Go Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken
Drug Purity given Rate of Administration and Dosing Interval
Go Drug Purity = (Drug Rate*Dosing Interval)/(Administered Dose*Bioavailability)
Rate of Administration of Drug given Dosing Interval
Go Drug Rate = (Administered Dose*Bioavailability*Drug Purity)/Dosing Interval
Drug Purity given Administrative Dose and Effective Dose
Go Drug Purity = Effective Dose/(Administered Dose*Bioavailability)
Drug Loading Efficiency
Go Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100
Encapsulation Efficiency
Go Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100
Renal Clearance of Drug
Go Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve
Concentration of Drug given Rate of Infusion of Drug
Go Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared
Rate of Infusion of Drug
Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug
Median Lethal Dose using Therapeutic Index
Go Median Lethal Dose = (Median Effective Dose*Therapeutic Index)
Margin of Safety of Drugs
Go Margin of Safety = Toxic Dose Response/Effective Dose Response
Effective Dose using Therapeutic Index
Go Median Effective Dose = Median Lethal Dose/Therapeutic Index
Therapeutic Index
Go Therapeutic Index = Median Lethal Dose/Median Effective Dose
Absorption Half-Life of Drug
Go Absorption Half Life = ln(2)/Absorption Rate Constant
Drug Rate Entering Body
Go Absorption Rate Constant = ln(2)/Absorption Half Life
Concentration of Drug using Volume of Distribution
Go Concentration of Drug = Dose/Volume of Distribution
Apparent Volume of Drug Distribution
Go Volume of Distribution = Dose/Concentration of Drug
Tablet Dosage
Go Number of tablet = Desired dosage/Stock strength
Easter Value
Go Easter Value = Saponification Value-Acid Value

Relative Bioavailability of Drug Formula

Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)
Frel = (AUCdosageA/AUCdosageB)*(DB/DA)

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Relative Bioavailability of Drug?

Relative Bioavailability of Drug calculator uses Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A) to calculate the Relative Bioavailability, The Relative bioavailability of drug formula is defined as the comparison of the bioavailability between two different dosage forms. Relative Bioavailability is denoted by Frel symbol.

How to calculate Relative Bioavailability of Drug using this online calculator? To use this online calculator for Relative Bioavailability of Drug, enter Area under curve Dosage A (AUCdosageA), Area under curve Dosage B (AUCdosageB), Dose Type B (DB) & Dose Type A (DA) and hit the calculate button. Here is how the Relative Bioavailability of Drug calculation can be explained with given input values -> 0.859273 = (1141/1732)*(15/11.5).

FAQ

What is Relative Bioavailability of Drug?
The Relative bioavailability of drug formula is defined as the comparison of the bioavailability between two different dosage forms and is represented as Frel = (AUCdosageA/AUCdosageB)*(DB/DA) or Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A). The Area under curve Dosage A is the integral of the concentration-time curve for A form of dosage, The Area under curve Dosage B is the integral of the concentration-time curve for B form of dosage, Dose Type B is the amount of drug administered in B-type dosage form & Dose Type A is the amount of drug administered in A-type dosage form.
How to calculate Relative Bioavailability of Drug?
The Relative bioavailability of drug formula is defined as the comparison of the bioavailability between two different dosage forms is calculated using Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A). To calculate Relative Bioavailability of Drug, you need Area under curve Dosage A (AUCdosageA), Area under curve Dosage B (AUCdosageB), Dose Type B (DB) & Dose Type A (DA). With our tool, you need to enter the respective value for Area under curve Dosage A, Area under curve Dosage B, Dose Type B & Dose Type A and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.
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