Volume of Distribution in Clearance of Drug Calculator

⤿

Volume of Distribution

Area under curve

Bioavailability

Dose

Drug Content

Drug Stability

Elimination Rate Constant

Isotonic Solutions

Plasma

Steady state Concentration

Volume of plasma cleared

✖The Elimination Rate Constant Drug is a constant that describes the rate at which a drug is eliminated from the body. It is often expressed in units of per time (1/time).ⓘ Elimination Rate Constant Drug [K]			+10% -10%
✖The Clearance of drug is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Clearance Of Drug [CL]			+10% -10%

✖The Volume of distribution clearance represents the apparent volume in the body available to contain the total amount of drug if it were distributed at the same concentration as in the plasma.ⓘ Volume of Distribution in Clearance of Drug [V_d]

⎘ Copy

👎

Formula

✖

Volume of Distribution in Clearance of Drug

Formula

`"V"_{"d"} = "K"/"CL"`

Example

`"1.1E^10L"="0.1min"/"2L/h"`

Calculator

LaTeX

Reset

👍

Download Pharmacokinetics Formula PDF PDF Image

Volume of Distribution in Clearance of Drug Solution

STEP 0: Pre-Calculation Summary

Formula Used

Volume of distribution clearance = Elimination Rate Constant Drug/Clearance Of Drug
V_d = K/CL
This formula uses 3 Variables

Variables Used

Volume of distribution clearance - (Measured in Cubic Meter) - The Volume of distribution clearance represents the apparent volume in the body available to contain the total amount of drug if it were distributed at the same concentration as in the plasma.
Elimination Rate Constant Drug - (Measured in Second) - The Elimination Rate Constant Drug is a constant that describes the rate at which a drug is eliminated from the body. It is often expressed in units of per time (1/time).
Clearance Of Drug - (Measured in Cubic Meter per Second) - The Clearance of drug is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

STEP 1: Convert Input(s) to Base Unit

Elimination Rate Constant Drug: 0.1 Minute --> 6 Second (Check conversion here)
Clearance Of Drug: 2 Liter per hour --> 5.55555555555556E-07 Cubic Meter per Second (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V_d = K/CL --> 6/5.55555555555556E-07

Evaluating ... ...

V_d = 10800000

STEP 3: Convert Result to Output's Unit

10800000 Cubic Meter -->10800000000 Liter (Check conversion here)

FINAL ANSWER

10800000000 ≈ 1.1E+10 Liter <-- Volume of distribution clearance

(Calculation completed in 00.004 seconds)

You are here -

Home » Chemistry » Pharmacokinetics » Volume of Distribution » Volume of Distribution in Clearance of Drug

Credits

Created by swapnalijadhav

idealinstituteofpharmacy (iip), Maharashtra

swapnalijadhav has created this Calculator and 10+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

Soupayan banerjee has verified this Calculator and 800+ more calculators!

< 5 Volume of Distribution Calculators

Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood

Go Volume of Distribution = Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))

Volume of Distribution given Elimination Half Life

Go Volume of Distribution = (Volume of Plasma Cleared*Elimination Half Life)/ln(2)

Volume of Distribution given Area under Curve

Go Volume of Distribution = Dose/(Elimination Rate Constant*Area Under Curve)

Volume of Distribution in Clearance of Drug

Go Volume of distribution clearance = Elimination Rate Constant Drug/Clearance Of Drug

Volume of Distribution given Volume of Plasma Cleared

Go Volume of Distribution = Volume of Plasma Cleared/Elimination Half Life

Volume of Distribution in Clearance of Drug Formula

Volume of distribution clearance = Elimination Rate Constant Drug/Clearance Of Drug
V_d = K/CL

What is difference between Clearance and Volume of Distribution?

Clearance and volume of distribution are both important pharmacokinetic parameters that help describe different aspects of how a drug behaves within the body, particularly in terms of its distribution and elimination.

How to Calculate Volume of Distribution in Clearance of Drug?

Volume of Distribution in Clearance of Drug calculator uses Volume of distribution clearance = Elimination Rate Constant Drug/Clearance Of Drug to calculate the Volume of distribution clearance, The Volume of Distribution in Clearance of Drug formula is the apparent volume in the body available to contain the total amount of drug if it were distributed at the same concentration as in the plasma. It's a ratio of the amount of drug in the body to its concentration in the plasma. Volume of distribution is often expressed in liters (L) or liters per kilogram (L/kg). Volume of distribution clearance is denoted by V_d symbol.

How to calculate Volume of Distribution in Clearance of Drug using this online calculator? To use this online calculator for Volume of Distribution in Clearance of Drug, enter Elimination Rate Constant Drug (K) & Clearance Of Drug (CL) and hit the calculate button. Here is how the Volume of Distribution in Clearance of Drug calculation can be explained with given input values -> 1.1E+13 = 6/5.55555555555556E-07.

FAQ

What is Volume of Distribution in Clearance of Drug?

The Volume of Distribution in Clearance of Drug formula is the apparent volume in the body available to contain the total amount of drug if it were distributed at the same concentration as in the plasma. It's a ratio of the amount of drug in the body to its concentration in the plasma. Volume of distribution is often expressed in liters (L) or liters per kilogram (L/kg) and is represented as V_d = K/CL or Volume of distribution clearance = Elimination Rate Constant Drug/Clearance Of Drug. The Elimination Rate Constant Drug is a constant that describes the rate at which a drug is eliminated from the body. It is often expressed in units of per time (1/time) & The Clearance of drug is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

How to calculate Volume of Distribution in Clearance of Drug?

The Volume of Distribution in Clearance of Drug formula is the apparent volume in the body available to contain the total amount of drug if it were distributed at the same concentration as in the plasma. It's a ratio of the amount of drug in the body to its concentration in the plasma. Volume of distribution is often expressed in liters (L) or liters per kilogram (L/kg) is calculated using Volume of distribution clearance = Elimination Rate Constant Drug/Clearance Of Drug. To calculate Volume of Distribution in Clearance of Drug, you need Elimination Rate Constant Drug (K) & Clearance Of Drug (CL). With our tool, you need to enter the respective value for Elimination Rate Constant Drug & Clearance Of Drug and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

Home

FREE PDFs

🔍 Search