Concentration of Drug given Rate of Infusion of Drug Calculator

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Drug Content

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Drug Stability

Elimination Rate Constant

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Plasma

Steady state Concentration

Volume of Distribution

Volume of plasma cleared

✖The Rate of Infusion is defined as the rate required to balance elimination.ⓘ Rate of Infusion [k_in]			+10% -10%
✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared [CL]			+10% -10%

✖Concentration of Drug is the amount of the drug in a given volume of plasma.ⓘ Concentration of Drug given Rate of Infusion of Drug [C_ss]

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Formula

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Concentration of Drug given Rate of Infusion of Drug

Formula

`"C"_{"ss"} = "k"_{"in"}/"CL"`

Example

`"114.5833mol/L"="55mol/s"/"0.48L/s"`

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Concentration of Drug given Rate of Infusion of Drug Solution

STEP 0: Pre-Calculation Summary

Formula Used

Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared
C_ss = k_in/CL
This formula uses 3 Variables

Variables Used

Concentration of Drug - (Measured in Mole per Cubic Meter) - Concentration of Drug is the amount of the drug in a given volume of plasma.
Rate of Infusion - (Measured in Mole per Second) - The Rate of Infusion is defined as the rate required to balance elimination.
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

STEP 1: Convert Input(s) to Base Unit

Rate of Infusion: 55 Mole per Second --> 55 Mole per Second No Conversion Required
Volume of Plasma Cleared: 0.48 Liter per Second --> 0.00048 Cubic Meter per Second (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

C_ss = k_in/CL --> 55/0.00048

Evaluating ... ...

C_ss = 114583.333333333

STEP 3: Convert Result to Output's Unit

114583.333333333 Mole per Cubic Meter -->114.583333333333 Mole per Liter (Check conversion here)

FINAL ANSWER

114.583333333333 ≈ 114.5833 Mole per Liter <-- Concentration of Drug

(Calculation completed in 00.004 seconds)

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K J Somaiya College of science (K J Somaiya), Mumbai

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Saponification value

Go Saponification Value = Molecular weight of KOH*(Volume of blank-Volume of Actual solution)*Normality of solution/Weight of sample taken

Fraction of Drug Unbound in Tissue given Apparent Tissue Volume

Go Fraction Unbound in Tissue = (Fraction Unbound in Plasma*Apparent Tissue Volume)/(Volume of Distribution-Plasma Volume)

Secretion Rate of Drug

Go Secretion Rate of Drug = (Renal Clearance*Plasma Concentration)-(Filtration Rate)+(Reabsorption Rate of Drug)

Reabsorption Rate of Drug

Go Reabsorption Rate of Drug = ((Renal Clearance*Plasma Concentration)+Filtration Rate+Secretion Rate of Drug)

Filtration Rate of Drug

Go Filtration Rate = ((Renal Clearance*Plasma Concentration)+Reabsorption Rate of Drug-Secretion Rate of Drug)

Relative Bioavailability of Drug

Go Relative Bioavailability = (Area under curve Dosage A/Area under curve Dosage B)*(Dose Type B/Dose Type A)

Acid Value of KOH

Go Acid Value = Molecular weight of KOH*Volume of solution koh*Normality of solution/Weight of sample taken

Drug Purity given Rate of Administration and Dosing Interval

Go Drug Purity = (Drug Rate*Dosing Interval)/(Administered Dose*Bioavailability)

Rate of Administration of Drug given Dosing Interval

Go Drug Rate = (Administered Dose*Bioavailability*Drug Purity)/Dosing Interval

Drug Purity given Administrative Dose and Effective Dose

Go Drug Purity = Effective Dose/(Administered Dose*Bioavailability)

Drug Loading Efficiency

Go Drug Loading Efficiency = Weight of drug in nanoparticles/Weight of the Nanoparticles*100

Encapsulation Efficiency

Go Encapsulation Efficiency = Weight of drug in nanoparticles/Weight of feeding drug*100

Renal Clearance of Drug

Go Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve

Concentration of Drug given Rate of Infusion of Drug

Go Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared

Rate of Infusion of Drug

Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug

Median Lethal Dose using Therapeutic Index

Go Median Lethal Dose = (Median Effective Dose*Therapeutic Index)

Margin of Safety of Drugs

Go Margin of Safety = Toxic Dose Response/Effective Dose Response

Effective Dose using Therapeutic Index

Go Median Effective Dose = Median Lethal Dose/Therapeutic Index

Therapeutic Index

Go Therapeutic Index = Median Lethal Dose/Median Effective Dose

Absorption Half-Life of Drug

Go Absorption Half Life = ln(2)/Absorption Rate Constant

Drug Rate Entering Body

Go Absorption Rate Constant = ln(2)/Absorption Half Life

Concentration of Drug using Volume of Distribution

Go Concentration of Drug = Dose/Volume of Distribution

Apparent Volume of Drug Distribution

Go Volume of Distribution = Dose/Concentration of Drug

Tablet Dosage

Go Number of tablet = Desired dosage/Stock strength

Easter Value

Go Easter Value = Saponification Value-Acid Value

Concentration of Drug given Rate of Infusion of Drug Formula

Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared
C_ss = k_in/CL

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Concentration of Drug given Rate of Infusion of Drug?

Concentration of Drug given Rate of Infusion of Drug calculator uses Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared to calculate the Concentration of Drug, The Concentration of drug given rate of infusion of drug formula is defined as the ratio of the rate of infusion required to balance elimination to the amount of drug in a given volume of plasma. Concentration of Drug is denoted by C_ss symbol.

How to calculate Concentration of Drug given Rate of Infusion of Drug using this online calculator? To use this online calculator for Concentration of Drug given Rate of Infusion of Drug, enter Rate of Infusion (k_in) & Volume of Plasma Cleared (CL) and hit the calculate button. Here is how the Concentration of Drug given Rate of Infusion of Drug calculation can be explained with given input values -> 0.114583 = 55/0.00048.

FAQ

What is Concentration of Drug given Rate of Infusion of Drug?

The Concentration of drug given rate of infusion of drug formula is defined as the ratio of the rate of infusion required to balance elimination to the amount of drug in a given volume of plasma and is represented as C_ss = k_in/CL or Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared. The Rate of Infusion is defined as the rate required to balance elimination & The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

How to calculate Concentration of Drug given Rate of Infusion of Drug?

The Concentration of drug given rate of infusion of drug formula is defined as the ratio of the rate of infusion required to balance elimination to the amount of drug in a given volume of plasma is calculated using Concentration of Drug = Rate of Infusion/Volume of Plasma Cleared. To calculate Concentration of Drug given Rate of Infusion of Drug, you need Rate of Infusion (k_in) & Volume of Plasma Cleared (CL). With our tool, you need to enter the respective value for Rate of Infusion & Volume of Plasma Cleared and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Concentration of Drug?

In this formula, Concentration of Drug uses Rate of Infusion & Volume of Plasma Cleared. We can use 1 other way(s) to calculate the same, which is/are as follows -

Concentration of Drug = Dose/Volume of Distribution

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